DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and slc6a9

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005163551.1	Gene:	slc6a9 / 494490	ZFINID:	ZDB-GENE-050105-3	Length:	653	Species:	Danio rerio

Alignment Length:	574	Identity:	206/574 - (35%)
Similarity:	332/574 - (57%)	Gaps:	41/574 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLL 111
            :...|.|||:.:||:::.:..:||||||||||:....||||||:.||.::|...|.|::::|:..
Zfish    27 ENSRRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFLELSF 91

  Fly   112 GQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG 176
            |||:|.|.:.|:..:|:.:||||..::....:..||..|:.:...|||.|..:.|||::|...|.
Zfish    92 GQFTSLGCLGVWKVSPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTNLLPWTYCNNPWN 156

  Fly   177 ----DGCVSASGGQPLQGQLSRNFSSSTQL------------YLQRIVLNETDSLEEGIGYPSGS 225
                .|.||..........:|...|..|::            |.:..|||    :.:||| ..|.
Zfish   157 TPDCSGVVSTHRANATFANMSAVVSGVTEIVNRTKRTSPSEEYWRNYVLN----ISDGIG-NFGE 216

  Fly   226 LAL----MLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTP 286
            :.|    .|.:||..|.|.:|||||||||..|..|.|||||:.||.:|.:||.||..|:.|:|||
Zfish   217 VRLPILGCLAVSWFVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFIRGITLDGAISGIKYYLTP 281

  Fly   287 QWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIF 351
            ||:|:|:.:||.:|.:|:|:||...:|.:|..:|||:|.:|.:||:.|::..:..||:.:|.:||
Zfish   282 QWQKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCFRDSIIISVTNCGTSVYAGFVIF 346

  Fly   352 GILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVS 416
            .|||.:||..|. |::.|...||||||::||:|:....:.| ::|||||.||.:||:|:...::.
Zfish   347 SILGFMAHHLGV-DVSEVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLGLGTQFCLLE 409

  Fly   417 CIMTVLKDQFVNVKLWII------VVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAI 475
            .::|.:.|:....  |||      .:.:::||||:|:...|..|.:.:.|||.:..:|..::.:.
Zfish   410 TLVTAVVDEIGTD--WIIKNKTYVTLGVAIIGFLLGVPLTTQAGIYWLLLMDNYAASFSLVIISC 472

  Fly   476 FELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFP 540
            ...|.:.::||.|...:|.|.||......::||||..|:|.::..||:::::..:|::||...:|
Zfish   473 IMCICIMYVYGHKNYFKDVEMMLGFPPPIFFRICWRYVSPFIITFILIFTVIQYKPITYNDYVYP 537

  Fly   541 LVYRVVGWCVSGCIIGQLFYWAGYANFK--QPKGS-LKSRINNSIKPHSDWGPS 591
            ....|:|:.::   :..:.....||.||  ..:|| ...|:.||:||..||||:
Zfish   538 GWSLVIGFAMA---LSSVICIPIYALFKIAMSEGSTFLERLKNSVKPDPDWGPA 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	184/499 (37%)
slc6a9	XP_005163551.1	SLC6sbd_GlyT1	15..598	CDD:212067	206/574 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820