DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and SLC6A17

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001010898.1	Gene:	SLC6A17 / 388662	HGNCID:	31399	Length:	727	Species:	Homo sapiens

Alignment Length:	581	Identity:	193/581 - (33%)
Similarity:	309/581 - (53%)	Gaps:	91/581 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KPSLLPMALESS------ELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAF 89
            |.|:|.:|.|:.      |...|.:.|..|.|.|:::::.|..||||||:||||:...:|||||:
Human    34 KQSVLNVAGEAGGKQKAVEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAY 98

  Fly    90 LIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDF-APLMRGVGYAQLLALGVLATYYASVMAL 153
            |:||||:|.::|.|::::|:.:||...||.:.|:.: .|.:.|:|::..:....:..||..::..
Human    99 LVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGW 163

  Fly   154 TLRYFFDSFASELPWSFC---REEWGDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSL 215
            ::.|||.||...||||.|   |    :|.|:.     ::.:..:  ||:|..:..|..|:.:||:
Human   164 SIFYFFKSFQYPLPWSECPVVR----NGSVAV-----VEAECEK--SSATTYFWYREALDISDSI 217

  Fly   216 EEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGV 280
            .|..|. :..:.|.|.::|..|.:.:::|::||||..|..:||||||:...|||.|.|.||.||:
Human   218 SESGGL-NWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGI 281

  Fly   281 MYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLL 345
            ::..||:.:|:|:||||..|.|||||:|.:.||.:|.:||||:..:|.:.||.:|:.::.|||:|
Human   282 LHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVL 346

  Fly   346 SGVIIFGILG------------------------------------NLAHESGTKD------IAS 368
            :.:::|.:||                                    |.:|.: |||      :..
Human   347 ATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLT-TKDYMEMYNVIM 410

  Fly   369 VVK----------------------AGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSN 411
            .||                      .|.|||||::.:|:..|...| .:|::||.||..||:||.
Human   411 TVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSM 474

  Fly   412 VGMVSCIMTVLKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIF 476
            :|.::.|.|.:.|.| .|...:..|...|..|||||:::...|.:.:|:.|.:..|....:..|.
Human   475 IGTMAGITTPIIDTF-KVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVIL 538

  Fly   477 ELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSL--LTMRPLSYN 535
            |.|||.||||||:..|:...||..:...:|...|..|:||.|.|:...|:  |.:.|..|:
Human   539 ENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	181/541 (33%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	186/555 (34%)
SLC6A17	NP_001010898.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820