DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a16

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001311464.1	Gene:	Slc6a16 / 381884	MGIID:	2685930	Length:	742	Species:	Mus musculus

Alignment Length:	596	Identity:	153/596 - (25%)
Similarity:	259/596 - (43%)	Gaps:	117/596 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KPSLLPMAL------ESSELSPDRKARDN---------WGSSLEFLMSCIALSVGLGNVWRFPFT 80
            |||:..:|.      ||||| .:|.:|::         |.|.:|::::.::..:....|.||...
Mouse    91 KPSVTELATVTTLEQESSEL-VNRMSRESSEGYPPRQLWASKVEYMLAIMSYLLMPSGVLRFASG 154

  Fly    81 ALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVF-DFAPLMRGVGYAQLLALGVLA 144
            .:..|..:|.|.|:::|..:|.|:.::||.:||.:.:....:: :.:|...||||:.::...:..
Mouse   155 WVHKGSCSFFIAYILMLLGIGIPLLFLEMAVGQRAQQSSADMWKNLSPWFGGVGYSMVMVCFITN 219

  Fly   145 TYYASVMALTLRYFFDSFASELPWSFCREEWGDGCVSASGGQPLQGQLSRNF------SSSTQLY 203
            ||.....:..|.|....|...:||..|               ||| :.|.||      ::|...:
Mouse   220 TYLNVFNSWILFYMSHIFYFVVPWDQC---------------PLQ-RNSSNFDPECEQATSYTYF 268

  Fly   204 LQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLV 268
            ..|..|..:|.:|:| |.||.||.:.|.:|:..:...::.|:||.||..:||.|.||.::...|:
Mouse   269 WYRKTLKASDRIEDG-GQPSFSLGMSLFLSFCLICAFLVNGIKSIGKVLFVLLLVPYSIIVCFLI 332

  Fly   269 RALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDAN 333
            |.|::.||..|:.:.|..:...:.:..:|.:|..||.|.:.:.||.|:..:|:....:|...||.
Mouse   333 RTLSMDGAEYGLKHLLILKVASISDLTIWCHAGIQVLFDIGLGFGPIVSLASHVPDFNNCMADAF 397

  Fly   334 IVTTLDTFTSLLSGVIIFGILG----NLAHESGTKD---IASVVKAGPGLAFISYPDA------- 384
            ::......|.|::...:..|||    ...|....|:   :..:|..|     |..|||
Mouse   398 LMALFKIITLLMTTPFLLSILGFWATTTTHHCCKKNQETLLRLVAQG-----ILPPDAQPPDLSG 457

  Fly   385 -----------------------------IAK------------FKMFPQVFSL---------LF 399
                                         :.|            |.:|.:|.||         ||
Mouse   458 NPTSNYNSWLSSLPPPLRSAVLSVVPECSVQKQFLKIKDNPRFLFLIFTEVISLLPGSGFWIVLF 522

  Fly   400 FAMLFMLGVGSNVGMVSCIMTVLKDQFV----NVKLWIIVVSLSVIGFLVGLIYITPGGQHIITL 460
            |.:|..||:.||:..:...:..|:|.|.    ..:|.|:.||:::  ||.|||:|.|.|.:..:|
Mouse   523 FLLLLTLGLCSNLMFMLGNVLTLQDTFPFCRRQPRLLIVCVSMAM--FLCGLIFIQPSGIYYFSL 585

  Fly   461 MDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL--V 523
            :....|....::..|.|.:||.|.||..|...|...:|.....:.....|..::|:|:|.:|  |
Mouse   586 LSECWVAVPVIIIIICENLAVAWAYGADRFLADMVALLGRPIFSGCGWLWCYISPMVVLGLLTSV 650

  Fly   524 YSLLTMRPLSY 534
            :..|...||.|
Mouse   651 FVYLVKGPLVY 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	138/559 (25%)
Slc6a16	NP_001311464.1	SLC5-6-like_sbd	125..694	CDD:294310	142/561 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920