DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and SerT

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	209/583 - (35%)
Similarity:	318/583 - (54%)	Gaps:	45/583 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PMA--LESSE----LSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYL 94
            |:|  |.::|    :|...:.|:.||...|||::.|..:|.||||||||:...:|||||||:||.
  Fly    53 PLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYC 117

  Fly    95 VVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTLRYF 158
            :.|...|.|::|||:.||||...|.:.::. ..|.::|||||..|....:..||.:::...:.|.
  Fly   118 LFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYL 182

  Fly   159 FDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNF----SSSTQLYLQRIVL-----NETD 213
            |.||.|:|||:.|...|. :.|:..:         |.||    :|..:.:.:|.||     |..|
  Fly   183 FASFTSKLPWTSCDNPWNTENCMQVT---------SENFTELATSPAKEFFERKVLESYKGNGLD 238

  Fly   214 SLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYD 278
            .:    |....:|||.:...::.|...:.:||:|:||..:|.||.||||:.|||||.::||||.:
  Fly   239 FM----GPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADE 299

  Fly   279 GVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTS 343
            |:.|:|||:|.||...:||.:|.:|:||||...||.::..||||:|.:|.||||.|.::::..||
  Fly   300 GIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTS 364

  Fly   344 LLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVF-SLLFFAMLFMLG 407
            .|:|.:||.:||.:|:...| .|..|...||||.||.||:|||  .|...|| |::||.||..||
  Fly   365 FLAGFVIFSVLGYMAYVQKT-SIDKVGLEGPGLVFIVYPEAIA--TMSGSVFWSIIFFLMLITLG 426

  Fly   408 VGSNVGMVSCIMTVLKDQFVNV---KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFV 469
            :.|..|.:..::|.|.|::..|   :..:.|:.|....||..|..:|.||..::..::.:|....
  Fly   427 LDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLA 491

  Fly   470 SLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSY 534
            .|.....|...|.|.||..|...|.|.||..|...::||||:.::|:.:|.|.::|::..:.:..
  Fly   492 ILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLG 556

  Fly   535 NGQEFPLVYRVVGWCVSG----CIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDP 593
            ....:|.....|||.|:.    ||...:.|...:|:    ||..:.|:..|.:|..:.|...|
  Fly   557 EEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFAS----KGGCRQRLQESFQPEDNCGSVVP 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	186/488 (38%)
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	201/552 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850