DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and CG8850

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_725122.2	Gene:	CG8850 / 36331	FlyBaseID:	FBgn0033708	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	314/622 - (50%)
Similarity:	440/622 - (70%)	Gaps:	34/622 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSGEALLKPSLLPMALESSELSPDRKA-------RDNWGSSLEFLMSCIALSVGLGNVWRFPFTA 81
            ||.:.:   |.:..:.|..||:.:.:|       ||.|...:|||.|||||||||||||||||.|
  Fly    26 GSNDGI---STVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIA 87

  Fly    82 LENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATY 146
            ||||||||||||::||.::|:|:||:|:::|||||||.::.||.||:|||:.|.|:.:..:..||
  Fly    88 LENGGGAFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTY 152

  Fly   147 YASVMALTLRYFFDSFASELPWSFCREEWGDGCV-----SASGGQPLQGQLSRNFSSSTQLYLQR 206
            ||.:||||:||...||:..|||::|..|||..||     :|:....:||      .||.:|:..:
  Fly   153 YACIMALTIRYLVASFSEVLPWTYCLVEWGKSCVATGATAANDSSIVQG------VSSAELFFTQ 211

  Fly   207 IVLNETDSLEE-GIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRA 270
            .||.|.:||:: |:|.||..|.|.|..:|:.:..|:.:|::|||||:|.|||||||:|.:||:||
  Fly   212 TVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRA 276

  Fly   271 LTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIV 335
            :|||||:.|::|||.|||.:||.|.|||.|:||:|||||:|||.::||:|:|.|..||::|..|:
  Fly   277 VTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIII 341

  Fly   336 TTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFF 400
            ||:|:.||:|:|.||||||||||.|:.||||:.|||.|.||||||||:||||||..||:|::|||
  Fly   342 TTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFF 406

  Fly   401 AMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHG 465
            .||.:||:|||:||.|.::.|:||:|.::..|::.||.|:||||.||:|:|||||.::.|:||:|
  Fly   407 FMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYG 471

  Fly   466 VTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMR 530
            .||::||.||.||:|||||||.||:|.|.|:|||:|||.|:||||:||.|.:|.::|||.|.:..
  Fly   472 CTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYE 536

  Fly   531 PLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKK 595
            ||:|.|.::|.||.:.||.:.|..:.||.:||....::||..:..|:...:::|.::|||...:|
  Fly   537 PLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQPTANWGPLQTQK 601

  Fly   596 LMDYQMFLRNKDEENSKNVNRRCVCYTAG---DRIFG 629
            ...|  .:..|.|.:.|:..       .|   |.|||
  Fly   602 FEAY--IIHRKREADFKSPR-------GGYLFDNIFG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	274/479 (57%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	274/479 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61415
OrthoDB	1	1.010	-	-		D14202at7147
OrthoFinder	1	1.000	-	-		FOG0008552
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.860