DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Ntl

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_609135.1	Gene:	Ntl / 34046	FlyBaseID:	FBgn0267326	Length:	590	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	204/584 - (34%)
Similarity:	337/584 - (57%)	Gaps:	39/584 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |..|.|..||::|.:..::|:|||||||:....:||.|||||||:::.:.|.|::|||:|:||||
  Fly    24 RGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILAGIPLFYMEILIGQFS 88

  Fly   116 SRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGC 179
            |.|...:|...||::|.|.||::.......||:.:::..:|..|..|..::||..|...|. |.|
  Fly    89 STGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKKVPWEDCSNSWNTDDC 153

  Fly   180 VSAS--GGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLIII 242
            |:||  |.|    ..|..|.:|...:....||..:..:.:..|.....|..:: |:|:.:...::
  Fly   154 VTASDMGKQ----NSSDVFKTSADEFFHLEVLRISTDISDLGGMVWEQLTALI-ITWIIIYFCLM 213

  Fly   243 RGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFS 307
            ||:||.||..|....|||:::||||:|..|||||:.|:.::|.|:|.:||:.:||.:|..|:||.
  Fly   214 RGIKSVGKVVYFTVPFPYLLLFILLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFG 278

  Fly   308 LAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKA 372
            :...:|.|:..:|::.|.:|...|:.::.:::.|||||:|.::|.:||.|:.:||. .:.||...
  Fly   279 IGPGWGGIVNMASFSSFRNNAKCDSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGI-PVESVATG 342

  Fly   373 GPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVKLWIIVVS 437
            |.||||::||:|||...: ||:::|:||.|||:||:.|....:..||:.:.|:      |..|.|
  Fly   343 GAGLAFVTYPEAIALLPV-PQLWALMFFFMLFLLGIDSVFVQLEAIMSSILDE------WYWVRS 400

  Fly   438 ----LSVIGFLVGL----IYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDA 494
                |::|..|:.|    |..|.||..|:.|.|::......:|..:.|:|.|.||||.|....|.
  Fly   401 HKCKLTLISCLIFLGLSSIMCTNGGMFILQLFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDV 465

  Fly   495 EYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGW--CVSGCIIGQ 557
            |:||..:.:.|:||.|.:|||::::.||:.|::.:|.::||...:|....::||  |.:..:...
  Fly   466 EFMLGKRPTLYWRIVWQVVTPVIIIFILITSIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIP 530

  Fly   558 LFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMDYQMFLRNK---------DEENSK 612
            |:.:  |...:: :.:|...:...:|| .||.|:||:...:|:.|.|.:         |.|:||
  Fly   531 LYIF--YIMIRK-RATLCDSLKKRLKP-LDWTPADPQDRAEYEAFRRQRRMPGFMSDTDMESSK 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	178/484 (37%)
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	190/545 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850