DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a14

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	218/607 - (35%)
Similarity:	335/607 - (55%)	Gaps:	60/607 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLL 111
            :.:.|.||....::|:|.:..:||||||||||:....||||||||||.::|.:.|.|::::|..|
  Rat    38 ENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSL 102

  Fly   112 GQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG 176
            |||:|.|.|.|:...||.:|||...:|....:..||..::|.:|.|.|.||.|.|||:.|...|.
  Rat   103 GQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANCSSSWA 167

  Fly   177 D----------GC-VSASGGQPLQGQL----SRNFSS------------STQLYLQRIVLNETDS 214
            |          || ||...|..:...:    |.||:.            .::.|..::.|..:..
  Rat   168 DDNCSRQPIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQLPSEQYWDKVTLRRSSG 232

  Fly   215 LEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDG 279
            ::| .|.....|||.|.::|:.|...:.:|:|||||..|..|||||||:.|||:|..||.||..|
  Rat   233 MDE-TGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKG 296

  Fly   280 VMYFLTPQ--WEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFT 342
            :.|::..|  :.||.|.:||.:|.||:|:||:|.:|.::..||||:|.:|.|.||.||...:..|
  Rat   297 ISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLT 361

  Fly   343 SLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLG 407
            |:.:|..||.|||::||.|| |:::.|||:|..||||:||:|:|:....| .:|:|||.||..||
  Rat   362 SVFAGFAIFSILGHMAHISG-KEVSQVVKSGFDLAFIAYPEALAQLPGGP-FWSILFFFMLLTLG 424

  Fly   408 VGSNVGMVSCIMTVLKDQFVN-VKLWIIVVSLS--VIGFLVGLIYITPGGQHIITLMDFHGVTFV 469
            :.|....:..|.|.::|.|.. :|...:.::|.  :|.||:||:.:|..|.:.:.|:|.....:.
  Rat   425 LDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLVCVTQAGIYWVHLIDHFCAGWG 489

  Fly   470 SLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNY---YRICWSIVTPLVMLVILVYSLLTMRP 531
            .|::||.|:..:.||||..|..:|.|.|:..|...:   :|.||.::||:::..|||:||:....
  Rat   490 ILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWFVITPILLSAILVWSLVKFHR 554

  Fly   532 LSYNGQEFPLVYRVVGWC-VSGCIIGQLFYW---AGYANFKQPKGSLKSRINNSIKPHSDWGP-- 590
            .:|....:|.....:||| :..|||     |   .......:.:|::..||....:|.|:|||
  Rat   555 PNYADIPYPDWGVALGWCMIIFCII-----WIPIMAIIKIVRAEGNILQRIIKCCRPASNWGPYL 614

  Fly   591 -----------SDPKKLMDYQM 601
                       ::|.|..|:::
  Rat   615 EKHRGERYKDMAEPAKETDHEI 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	195/508 (38%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	218/603 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920