DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	209/593 - (35%)
Similarity:	317/593 - (53%)	Gaps:	64/593 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLKPS--LLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLI 91
            :||||  ..|......|.......|:.|.|.::|::|.....||||||||||:...:||||||||
  Rat    27 ILKPSPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLI 91

  Fly    92 PYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTL 155
            ||.:.||..|.|::::|:::||::|.|.:..:: ..||..|:|||.::.:.:|..||..::|...
  Rat    92 PYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWAT 156

  Fly   156 RYFFDSFASELPWSFCREEWGDGCVSASGGQPLQGQLSR-----------NFSSSTQLYLQRIVL 209
            .|.|.||..:|||:.|...|       :..|.::..|.|           ||:|....:.:|.||
  Rat   157 YYLFQSFQKDLPWAHCNHSW-------NTPQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVL 214

  Fly   210 NETDSLEEGIGYPSG---SLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRAL 271
                ||..||.:|..   .|||.|.:.||.....|.:||:|:||..|..|.||:.::.:||||.|
  Rat   215 ----SLSSGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGL 275

  Fly   272 TLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVT 336
            |||||.:|:.::|.|...:|.:||||.:|.||:|||.|:|.|.:....|||::.:|.|||..::.
  Rat   276 TLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLG 340

  Fly   337 TLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFA 401
            .|::.||.:||..||.|||.:|.|.|. |||.|.::|||||||:||.|:....: |..:|:|||.
  Rat   341 CLNSGTSFVSGFAIFSILGFMAQEQGV-DIADVAESGPGLAFIAYPKAVTMMPL-PTFWSILFFI 403

  Fly   402 MLFMLGVGSNVGMVSCIMTVLKDQFVN-----VKLWIIVVSLSVIGFLVGLIYITPGGQHIITLM 461
            ||.:||:.|....|...:|.|.|.:.:     .:..|.:..:..|.:|:||..:|.||.::..|.
  Rat   404 MLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSISYLLGLTMVTEGGMYVFQLF 468

  Fly   462 DFHGVTFVSLV-SAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYS 525
            |::..:.|.|: .|.||...:.||||...|....|.|:..:...:.:..|:::||.:.:...::|
  Rat   469 DYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFIFS 533

  Fly   526 LLTMRPLSYNGQEFPLVYRV------VGW--------CVSGCIIGQLFYWAGYANFKQPKGSLKS 576
            |:...||:||     .|||.      :||        |:...|:..|.         :.:|.|:.
  Rat   534 LVKYVPLTYN-----KVYRYPDWAIGLGWGLALSSMVCIPLVIVILLC---------RTEGPLRV 584

  Fly   577 RINNSIKP 584
            ||...|.|
  Rat   585 RIKYLITP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	182/494 (37%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	202/567 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820