DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and CG33296

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	138/613 - (22%)
Similarity:	261/613 - (42%)	Gaps:	83/613 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTAL 82
            |||..:|:     ||           .|||.| |..|....::|.:|..|::.| :::...:...
  Fly     4 ETSYASGT-----KP-----------FSPDPK-RGKWEKPTDYLFACFGLALKL-DIFEVSYWFF 50

  Fly    83 ENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYY 147
            .|.|...::||.:.:.:...||..:...:|||||.|.:..|..|||.:|:||..:........||
  Fly    51 FNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYY 115

  Fly   148 ASVMALTLRYFFDSFASELPWSFCR---------EEWGDGCVSASGGQPLQGQLSRNFS----SS 199
            :..:|:.|.:..:||...|||| |.         :|:...|      .|...:...|::    :.
  Fly   116 SMFVAIPLLFLINSFRPTLPWS-CEGLKSWHNRTDEYPTLC------HPTIYKQHENYTLGVEAP 173

  Fly   200 TQLYLQRIVLN--ETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSS--GKAAYVLALFPY 260
            ::||...|..:  .||...: |..|   |..:..:||..:.:|.....:.:  ||....:.:...
  Fly   174 SRLYFDYIRQDYFNTDKRFD-ISRP---LIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTM 234

  Fly   261 VVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFG 325
            |::.:..||.|.|||::..:..::||..:...|.  .|:.......:....:|.:|..||:|.|.
  Fly   235 VLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEG--IYSTFIMALQAFGAGWGSVIALSSFNGFK 297

  Fly   326 HNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVK----AGPGLAFISYPDAIA 386
            .::...:.|::....|..::.|::.|.:      |...|||:..:.    ....:.|:|...|:.
  Fly   298 TDIMSYSWIISFGQIFIYIMFGLVSFML------EQYYKDISDTIVFHRIMNFWVLFLSSASALN 356

  Fly   387 KFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVK------LWIIVVSLSVIGFLV 445
            ... :|.:::.::::||.:..:......:..::..|.|:|..:|      .:.|:..|::..|
  Fly   357 TLG-WPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSF-- 418

  Fly   446 GLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICW 510
              .:.|..|.....::....:...||:..:. |:.|.||||.||..:|.|:||....:::.....
  Fly   419 --FFCTEHGSFYFAILGIDVILAHSLLHLLL-LLVVLWIYGQKRFQRDIEFMLGQPFASWKVFIL 480

  Fly   511 SIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWA----GYANFKQPK 571
            ....|:|.|:.::..::....:.:..:|..||.        |.|:..|.:.|    |:...:|..
  Fly   481 RYTAPIVFLICMILGIIECIRVHFFFKEVFLVL--------GIILVVLPFLAIPGYGFYYLRQSP 537

  Fly   572 GSLKSRINNSIKPHSDWGPSDPKKLMDY 599
            |:...|:..|.:| :||.|.:.|....|
  Fly   538 GTFLERLKRSCRP-TDWYPVEMKHRQHY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	109/500 (22%)
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	108/494 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840