Protein Alignment CG4476 and Slc6a4

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 205/613 - (33%)
• Similarity: 339/613 - (55%)
• Gaps: 43/613 - (7%)

  Fly     2 KDLKTEILVSGGLP----KLETSRCAGSGEALLKPSL-------LPMALESSELSPDRKARDNWG 55
            :|.:...::..|:|    :.|.|:.:....|:...|.       :|.|..:......:..|:.||
  Rat    19 EDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWG 83

  Fly    56 SSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIV 120
            ..::||:|.|..:|.|||:||||:...:|||||||:||.::....|.|::|||:.|||:...|.:
  Rat    84 KKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCI 148

  Fly   121 QVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGDG-CVSAS 183
            .:: ...|:.:|:|||..:....:|:||.:::|..|.|...|....|||:.|...|..| |.:..
  Rat   149 SIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYF 213

  Fly   184 GGQPLQGQLSRNFSSSTQLYLQRIV-LNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKS 247
            ....:...| .:.|.:.:.||:.:: ::::..|:: :|..|..|.|.:.:.:..:...|.:|||:
  Rat   214 AQDNITWTL-HSTSPAEEFYLRHVLQIHQSKGLQD-LGTISWQLTLCIVLIFTVIYFSIWKGVKT 276

  Fly   248 SGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCF 312
            |||..:|.|.|||:|:.:||||..|||||:.||:::|.|.|:||||..||.:|..|:||||...|
  Rat   277 SGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGF 341

  Fly   313 GVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVK-AGPGL 376
            ||::.::|||:|.:|.|:||.:.:.::..||.:||.:||.:||.:| |...:|::.|.| |||.|
  Rat   342 GVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSL 405

  Fly   377 AFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV----KLW--IIV 435
            .||:|.:|||.... ...|:::||.||..||:.|....:..::|.:.|:|.::    :.|  :||
  Rat   406 LFITYAEAIANMPA-STFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIV 469

  Fly   436 VSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNI 500
            |...|:|   .|:.:|.||.:::||::.:......|..|:.|.:||.|.||..:.|.|.:.||..
  Rat   470 VITCVLG---SLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGF 531

  Fly   501 KTSNYYRICWSIVTPLVMLVILVYSLLT---MRPLSYNGQEFPLVYRVVGWCVSG----CIIGQL 558
            ....::||||..::||.:|.|:...|::   :|...||   :|....|:|:|:..    ||...:
  Rat   532 SPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYN---YPHWSIVLGYCIGMSSVICIPTYI 593

  Fly   559 FYWAGYANFKQPKGSLKSRINNSIKPHS 586
            .|     ......|:||.||..||.|.:
  Rat   594 IY-----RLISTPGTLKERIIKSITPET 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	176/483 (36%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		6/36 (17%)
		5HT_transport_N	24..64	CDD:397524	6/39 (15%)
		SLC6sbd_SERT	79..615	CDD:271399	195/550 (35%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920