Protein Alignment CG4476 and Slc6a1

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 599
• Identity: 205/599 - (34%)
• Similarity: 341/599 - (56%)
• Gaps: 32/599 - (5%)

  Fly    10 VSGGLPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNV 74
            |:.|....|.|....:.:   ||..|.:.::..  :.|...||.|....:|||||:..::|||||
Mouse     8 VADGQISTEVSEAPVASD---KPKTLVVKVQKK--AGDLPDRDTWKGRFDFLMSCVGYAIGLGNV 67

  Fly    75 WRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLA 139
            ||||:...:||||||||||.:.|...|.|::.:|..|||::|.|.:.|:..||:.:|||.|..:.
Mouse    68 WRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVL 132

  Fly   140 LGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSSTQLY 203
            ...|..||..:::..:.|.::||.:.|||..|...|. |.|.|   ...|..  :.|.:|:...:
Mouse   133 SFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFS---NYSLVN--TTNMTSAVVEF 192

  Fly   204 LQRIVLNETDSLEE--GIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFIL 266
            .:|.:...||.|::  .|.:|   ||:.|.|:|:.|...|.:||..:||..|..|.:||:::.||
Mouse   193 WERNMHQMTDGLDKPGQIRWP---LAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIIL 254

  Fly   267 LVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRD 331
            ..|.:|||||.:|:::::||.:.||.:.:||.:|.||:|||..:..|.:|...|||.|.:|||||
Mouse   255 FFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRD 319

  Fly   332 ANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFS 396
            :.||..:::.||:.:|.:||.|:|.:||.: .:.||.|..:||||||::||:|:.:..:.| :::
Mouse   320 SIIVCCINSCTSMFAGFVIFSIVGFMAHVT-KRSIADVAASGPGLAFLAYPEAVTQLPISP-LWA 382

  Fly   397 LLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---KLWIIVVSLSVIGFLVGLIYITPGGQHII 458
            :|||:||.|||:.|....|...:|.|.|::..:   :..:.:.::.::.:|:||..||.||.::.
Mouse   383 ILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVF 447

  Fly   459 TLMDFHGVTFVSLVSAI-FELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVIL 522
            .|.|::..:.:||:..: ||.:::.|.||..|...:.:.|:..:...::::|||..||:::..:.
Mouse   448 KLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVF 512

  Fly   523 VYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYA--NFKQPKGSLKSRINNSIKPH 585
            ::|.:.|.||:.....||...:.|||.::   :..:....||.  .|...|||||.|:...|:|.
Mouse   513 LFSAVQMTPLTMGSYVFPKWGQGVGWLMA---LSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPS 574

  Fly   586 SDW-----GPSDPK 594
            .|.     ||..|:
Mouse   575 EDIVRPENGPEQPQ 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	172/480 (36%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/14 (29%)
		SLC6sbd_GAT1	2..599	CDD:212075	205/599 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		3/12 (25%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820