DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	600	Identity:	215/600 - (35%)
Similarity:	333/600 - (55%)	Gaps:	41/600 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GG---LPKLETSRCAGSGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGN 73
            ||   ||:.....|..:...::|.......|.:|:.| |.:.|:.||..::||:|.:..:|.|.|
Mouse    15 GGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDS-DAQPRETWGKKIDFLLSVVGFAVDLAN 78

  Fly    74 VWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLL 138
            |||||:...:||||||||||.:.|.:.|.|::|||:.|||::..|...|:...|..:|||||.:|
Mouse    79 VWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVIL 143

  Fly   139 ALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWGD-GC-----VSASGGQPLQGQLSR--- 194
            ....:..||..::|.:|.|.|.||...|||:.|...|.. .|     ::||    :.|..::
Mouse   144 IALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNAS----VLGDHTKYSK 204

  Fly   195 -NFSSSTQLYLQRIV-LNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLAL 257
             .|:.:.:.|.:.:: |:|:..:.: ||.|...|.|.|.:..:.:...:.:|||:|||..::.|.
Mouse   205 YKFTPAAEFYERGVLHLHESSGIHD-IGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITAT 268

  Fly   258 FPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYN 322
            .||.|:|:|||..:|||||.:|:..:|...:.:|.|..||.:|.||:||||...|||:|.::|||
Mouse   269 LPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYN 333

  Fly   323 RFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAK 387
            :|.:|.||||.:.:|::..||.:||..||.|||.:|||... :|..|...|.||.||.||:||:.
Mouse   334 KFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKV-NIEDVATEGAGLVFILYPEAIST 397

  Fly   388 FKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFV----NVKLWIIVVSLSVIGFLVGLI 448
            .. ....:::|||.||..||:.|::|.:..::|.|.|.|.    :.||:..||::|.  ||:.|.
Mouse   398 LS-GSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTIST--FLLALF 459

  Fly   449 YITPGGQHIITLMDFHGVTFVSLVSAIF----ELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRIC 509
            .||.||.:::||:|    ||.:..|.:|    |.|.|.|.||..|...|.:.|:..|...|:|:|
Mouse   460 CITKGGIYVLTLLD----TFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLC 520

  Fly   510 WSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFK--QPKG 572
            |..|:|..:|.::|.|::..:||:|:...:|.....|||   |..:..:.....|..:|  ..:|
Mouse   521 WKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGW---GIALSSMILVPAYVIYKFLSIRG 582

  Fly   573 SLKSRINNSIKPHSD 587
            ||..|:...|.|.::
Mouse   583 SLWERVAYGITPENE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	187/492 (38%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/5 (40%)
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	205/557 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820