DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a13

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006237280.2	Gene:	Slc6a13 / 171163	RGDID:	620788	Length:	608	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	196/552 - (35%)
Similarity:	311/552 - (56%)	Gaps:	19/552 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |:.|.:.:||::|.....:|||||||||:...:||||||.||||:.||..|.|::::|..|||::
  Rat    32 REQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYT 96

  Fly   116 SRG-------IVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCRE 173
            ::|       |..:|:.:....|:|||..:.:.:|..||..|:|..|.|.|.||.::|||..|..
  Rat    97 NQGGITAWRKICPIFEASVPSPGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSH 161

  Fly   174 EWG-DGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTV 237
            ||. :.||............|.|.:|....:.:|.||..:|.::. :|.....|.|.|.::|:..
  Rat   162 EWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQH-LGSLRWELVLCLLLAWIIC 225

  Fly   238 TLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVT 302
            ...|.:||||:||..|..|.|||:::.:||:|.:|||||..|:.::|.|...:|.:||||.:|.|
  Rat   226 YFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGT 290

  Fly   303 QVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIA 367
            |:|||.|:|.|.:....|||::.:|.|||...:..|::.||.::|..||.|||.::.|.|. .|:
  Rat   291 QIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILGFMSQEQGV-PIS 354

  Fly   368 SVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV--- 429
            .|.::|||||||:||.|:......| :::..||.|:.:||:.|....|..::|.|.|.:..|
  Rat   355 EVAESGPGLAFIAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRK 418

  Fly   430 --KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGTKRLC 491
              :..|:::.:||:.|.:|||.:|.||.::..|.|::..:.:.|: .||||.:.|.|:||..|..
  Rat   419 KNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGASRFY 483

  Fly   492 QDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQ-EFPLVYRVVGWCVSGCII 555
            .:.|.|:..|.....:.||...||.|.|...::||:...||:||.: .:|.....:||.::...:
  Rat   484 DNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSM 548

  Fly   556 GQLFYWAGYANFKQPKGSLKSRINNSIKPHSD 587
            ..:..|:.| ..:..||.|:.|:...:.|..|
  Rat   549 VCIPAWSIY-KLRTLKGPLRERLRQLVCPAED 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	178/487 (37%)
Slc6a13	XP_006237280.2	SLC5-6-like_sbd	32..581	CDD:382020	196/552 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820