DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001342104.1	Gene:	Slc6a9 / 14664	MGIID:	95760	Length:	652	Species:	Mus musculus

Alignment Length:	589	Identity:	218/589 - (37%)
Similarity:	346/589 - (58%)	Gaps:	52/589 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ALESSELSPDRK-ARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVG 101
            |:.|.....|:. .|.|||:.:||:::.:..:||||||||||:....||||||:.||.::|...|
Mouse    32 AVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCG 96

  Fly   102 KPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASEL 166
            .|:::||:..|||:|:|.:.|:..:|:.:||||..::....:..||..|:.:...|||.|....|
Mouse    97 IPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVL 161

  Fly   167 PWSFCREEWGD----GCVSAS----GGQP--LQGQLSRNF------SSSTQLYLQRIVLNETDSL 215
            ||::|...|..    |.:.||    |.:|  |.|.||..|      :|.::.|.:..||    .|
Mouse   162 PWAYCNNPWNTPDCAGVLDASNLTNGSRPAALSGNLSHLFNYTLQRTSPSEEYWRLYVL----KL 222

  Fly   216 EEGIG-YPSGSLALM--LGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAY 277
            .:.|| :....|.|:  ||:||:.|.|.:|||||||||..|..|.|||||:.||.||.:||.||:
Mouse   223 SDDIGNFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAF 287

  Fly   278 DGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFT 342
            .|:||:|||||:|:||.:||.:|.:|:|:||...:|.:|..:|||:|.:|.|||:.|::..:..|
Mouse   288 TGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCAT 352

  Fly   343 SLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLG 407
            |:.:|.:||.|||.:|:..|. |::.|...||||||::||:|:....:.| ::|||||.||.:||
Mouse   353 SVYAGFVIFSILGFMANHLGV-DVSRVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLG 415

  Fly   408 VGSNVGMVSCIMTVLKDQFVNVKLWI------IVVSLSVIGFLVGLIYITPGGQHIITLMDFHGV 466
            :|:...::..::|.:.|:..|.  ||      :.:.::|.|||:|:...:..|.:.:.|||.:..
Mouse   416 LGTQFCLLETLVTAIVDEVGNE--WILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAA 478

  Fly   467 TFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRP 531
            :|..:|.:....:::.:|||.:...||.:.||......:::|||..|:|.::..||:::::..||
Mouse   479 SFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILIFTVIQYRP 543

  Fly   532 LSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAG------YANF---KQPKGSLKSRINNSIKPHSD 587
            ::||..::|      ||.|:   ||.|...:.      ||.|   :....:|..|:.|:.||..|
Mouse   544 ITYNHYQYP------GWAVA---IGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRD 599

  Fly   588 WGPS 591
            |||:
Mouse   600 WGPA 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	191/498 (38%)
Slc6a9	NP_001342104.1	SLC6sbd_GlyT1	30..613	CDD:212067	218/589 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820