Protein Alignment CG4476 and Slc6a3

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 585
• Identity: 200/585 - (34%)
• Similarity: 323/585 - (55%)
• Gaps: 34/585 - (5%)

  Fly    25 SGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAF 89
            :...|:.|...|:.::.         |:.|...::||:|.|..:|.|.||||||:...:||||||
Mouse    43 TNSTLINPPQTPVEVQE---------RETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAF 98

  Fly    90 LIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALT 154
            |:|||:.:.:.|.|::|||:.||||:..|...|:...|:::|||:..:|....:..:|..::|..
Mouse    99 LVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWA 163

  Fly   155 LRYFFDSFASELPWSFCREEWGD-GCVSASGGQPLQG-QLSRNFSSSTQL-YLQRIV--LNETDS 214
            |.|||.||..:|||..|...|.. .|..|.......| .|:..|.::... |.:|.|  |:::..
Mouse   164 LHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRG 228

  Fly   215 LEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDG 279
            ::: :|.|...|...|.:..:.:...:.:|||:|||..::.|..||||:..||:|.:|||||.||
Mouse   229 IDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDG 292

  Fly   280 VMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSL 344
            :..:|:..:.:|.|..||.:|.|||.|||.|.|||:|.:||||:|.:|.||||.|.|::::.||.
Mouse   293 IRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSF 357

  Fly   345 LSGVIIFGILGNLA--HESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLG 407
            .||.::|..||.:|  |....:|:|:   .||||.||.||:|||...: ...::.:||.||..||
Mouse   358 SSGFVVFSFLGYMAQKHNVPIRDVAT---DGPGLIFIIYPEAIATLPL-SSAWAAVFFLMLLTLG 418

  Fly   408 VGSNVGMVSCIMTVLKDQFV----NVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTF 468
            :.|.:|.:..::|.|.|:|.    :.:|:.:.:.|:.  ||:.|..:|.||.::.||:|......
Mouse   419 IDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLAT--FLLSLFCVTNGGIYVFTLLDHFAAGT 481

  Fly   469 VSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLS 533
            ..|...:.|.|.|.|.||.::...|.:.|...:.:.|:|:||.:|:|..:|.::|.|::|.||..
Mouse   482 SILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPH 546

  Fly   534 YNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMD 598
            |....||.....:||.::...:..:..:|.| .|....||.:.::..:|.|..|      ::|:|
Mouse   547 YGAYIFPDWANALGWIIATSSMAMVPIYATY-KFCSLPGSFREKLAYAITPEKD------RQLVD 604

  Fly   599  598
            Mouse   605  604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	177/484 (37%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:294310	197/559 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		7/29 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820