DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	614	Identity:	237/614 - (38%)
Similarity:	342/614 - (55%)	Gaps:	57/614 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EALLK----PSLL--PMALESSELSPDRKA-RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALEN 84
            ||.|:    |.||  |......:|..|..| |.||...|:||:|||...||||||||||:.|..|
  Rat     6 EAHLRKPVTPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTN 70

  Fly    85 GGGAFLIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYAS 149
            ||||||:||.::|.:.|.|::::|:.||||||.|.:.|:..:||.:|.|.|.||.:|::|.||..
  Rat    71 GGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNM 135

  Fly   150 VMALTLRYFFDSFASELPWSFCREEWG-DGCVSASGGQPLQGQLSRNFSSS---TQLYLQRIVLN 210
            ::|..|.|.|.|..|.|||..|...|. :.|:...|.:...|.|..|.||:   ::.|..|.||:
  Rat   136 IIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWSRYVLH 200

  Fly   211 ETDSLEEGIGYPS---GSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALT 272
            ...|  :|||.|.   .:|.|.|.::|:.|.|.|::|||||||..|..|.|||:::.:||||.:|
  Rat   201 IQGS--QGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVT 263

  Fly   273 LPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTT 337
            ||||:.|:.::||||:..||..:||..|..|:|:||.|.||.::.::|||.|..|:|||..|||.
  Rat   264 LPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTL 328

  Fly   338 LDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAM 402
            .:..||:|:|..||.:||.::.|.|. .:..|.||||||||:.||.|:....:.| .:|.|||.|
  Rat   329 GNAITSILAGFAIFSVLGYMSQELGV-PVDQVAKAGPGLAFVVYPQAMTMLPLSP-FWSFLFFFM 391

  Fly   403 LFMLGVGSNVGMVSCIMTVLKDQF---VNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFH 464
            |..||:.|....:..|:|.:.|:|   :..|..:....:.|..:|:|||..|.||.:.:.|:|.:
  Rat   392 LLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDY 456

  Fly   465 GVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTM 529
            ..:|..:|..|...:||..:||.:|.|:|...||..|...|:|.||..::|..:|.:||||::..
  Rat   457 SASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKY 521

  Fly   530 RPLSYNGQEFPLVYRVVG------WCV---SGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPH 585
            :|..|....||....::|      .|:   :|.::..|          :.:|||..|:..:.:|.
  Rat   522 QPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVL----------REEGSLWERLQQASRPA 576

  Fly   586 SDWGPS-----------------DPKKLM 597
            .|||||                 .||.||
  Rat   577 IDWGPSLEENRTGMYVATLAGSQSPKPLM 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	203/483 (42%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	220/557 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920