DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	215/588 - (36%)
Similarity:	346/588 - (58%)	Gaps:	50/588 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ALESSELSPDRK-ARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVG 101
            |:.|.....|:. .|.|||:.:||:::.:..:||||||||||:....||||||:.||.::|...|
  Rat    18 AVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCG 82

  Fly   102 KPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASEL 166
            .|:::||:..|||:|:|.:.|:..:|:.:||||..::....:..||..|:.:...|||.|....|
  Rat    83 IPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVL 147

  Fly   167 PWSFCREEWGD----GCVSAS----GGQP--LQGQLSRNF------SSSTQLYLQRIVLNETDSL 215
            ||::|...|..    |.:.||    |.:|  |.|.||..|      :|.::.|.:..||..:|.:
  Rat   148 PWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDI 212

  Fly   216 EEGIGYPSGSLALM--LGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYD 278
            .:   :....|.|:  ||:||:.|.|.:|||||||||..|..|.|||||:.||.||.:||.||:.
  Rat   213 GD---FGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFT 274

  Fly   279 GVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTS 343
            |:||:|||:|:|:||.:||.:|.:|:|:||...:|.:|..:|||:|.:|.|||:.|::..:..||
  Rat   275 GIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATS 339

  Fly   344 LLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGV 408
            :.:|.:||.|||.:|:..|. |::.|...||||||::||:|:....:.| ::|||||.||.:||:
  Rat   340 VYAGFVIFSILGFMANHLGV-DVSRVADHGPGLAFVAYPEALTLLPISP-LWSLLFFFMLILLGL 402

  Fly   409 GSNVGMVSCIMTVLKDQFVNVKLWI------IVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVT 467
            |:...::..::|.:.|:..|.  ||      :.:.::|.|||:|:...:..|.:.:.|||.:..:
  Rat   403 GTQFCLLETLVTAIVDEVGNE--WILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAAS 465

  Fly   468 FVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPL 532
            |..:|.:....:::.:|||.:...||.:.||......:::|||..|:|.::..||:::::..||:
  Rat   466 FSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPI 530

  Fly   533 SYNGQEFPLVYRVVGWCVSGCIIGQLFYWAG------YANF---KQPKGSLKSRINNSIKPHSDW 588
            :||..::|      ||.|:   ||.|...:.      ||.|   :....:|..|:.|:.||..||
  Rat   531 TYNHYQYP------GWAVA---IGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDW 586

  Fly   589 GPS 591
            ||:
  Rat   587 GPA 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	188/497 (38%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	215/588 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820