Protein Alignment CG4476 and SLC6A14

DIOPT Version :9

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 221/618 - (35%)
• Similarity: 334/618 - (54%)
• Gaps: 80/618 - (12%)

  Fly    47 DRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLL 111
            :.:.|.||....::|:|.|..:||||||||||:....||||||||||.::|.:.|.|::::|..|
Human    32 ENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSL 96

  Fly   112 GQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG 176
            |||:|.|.|.|:...||.:|||...:|....:..||..::|.:|.|.|.||.|||||..| ..|.
Human    97 GQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNC-SSWS 160

  Fly   177 D-------------------------------------GCVSASG-GQPLQGQLSRNFSSSTQLY 203
            |                                     .|::.|. .||  |||      .::.|
Human   161 DKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQP--GQL------PSEQY 217

  Fly   204 LQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLV 268
            ..::.|..:..:.| .|.....|||.|.::||.|...:.:|:|||||..|..|||||||:.||||
Human   218 WNKVALQRSSGMNE-TGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLV 281

  Fly   269 RALTLPGAYDGVMYFLTPQ--WEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRD 331
            |..||.||..|:.|::..|  :.||.|.:||.:|.||:|:||:|.:|.::..||||:|.:|.:.|
Human   282 RGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSD 346

  Fly   332 ANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFS 396
            |.:|...:..||:.:|..||.|||::||.|| |:::.|||:|..||||:||:|:|:....| .:|
Human   347 AIVVCLTNCLTSVFAGFAIFSILGHMAHISG-KEVSQVVKSGFDLAFIAYPEALAQLPGGP-FWS 409

  Fly   397 LLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV--KLWI-IVVSLSVIGFLVGLIYITPGGQHII 458
            :|||.||..||:.|....:..|.|.::|.|..|  |:.: |.:...::.||:||:.:|..|.:.:
Human   410 ILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWV 474

  Fly   459 TLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNY---YRICWSIVTPLVMLV 520
            .|:|.....:..|::||.||:.:.||||..|..:|.|.|:..|...:   :|.||.::||::::.
Human   475 HLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIA 539

  Fly   521 ILVYSLLTMRPLSYNGQEFPLVYRVVGWC-VSGCIIGQLFYW---AGYANFKQPKGSLKSRINNS 581
            |.::||:.....:|....:|.....:||| :..|||     |   .......|.||::..|:.:.
Human   540 IFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCII-----WIPIMAIIKIIQAKGNIFQRLISC 599

  Fly   582 IKPHSDWGP-------------SDPKKLMDYQM 601
            .:|.|:|||             .||||..|:::
Human   600 CRPASNWGPYLEQHRGERYKDMVDPKKEADHEI 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	195/519 (38%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	221/614 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642		5/11 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920