DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and Slc6a15

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001239259.1	Gene:	Slc6a15 / 103098	MGIID:	2143484	Length:	729	Species:	Mus musculus

Alignment Length:	593	Identity:	194/593 - (32%)
Similarity:	308/593 - (51%)	Gaps:	102/593 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGK 102
            |.:.||...:|.|   |.|.|:::::.:..|||||||||||:...:|||||:|:|||::|.|:|.
Mouse    51 AEDGSEADDERPA---WNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGI 112

  Fly   103 PIYYMEMLLGQFSSRGIVQVFDF-APLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASEL 166
            |::::|:.:||...||.:.|::: :|.:.|:|:|..:....:|.||..::..||.||..||...|
Mouse   113 PLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPL 177

  Fly   167 PWSFCREEWGDGCVSASGGQPLQGQLSRNF-------SSSTQLYLQRIVLNETDSLEEGIGYPSG 224
            ||..|               ||....|..:       ||:|..|..|..|:.|.|:.:..|. :.
Mouse   178 PWDQC---------------PLVKNASHTYVEPECEQSSATTYYWYREALDITSSISDSGGL-NW 226

  Fly   225 SLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWE 289
            .:.:.|.::|:.|.|.:|:|::||||..|..:||||||:...|:|:|.|.|:.||:.:..||:.|
Mouse   227 KMTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLE 291

  Fly   290 KLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGIL 354
            .:|||:||..|.|||||:|.:.||.:|.:||||:..:|.:.||.:|:.::.|||:|:.:::|.:|
Mouse   292 MMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVL 356

  Fly   355 G---NLAHESGTK--------------------------------------DIASVVK------- 371
            |   |:.:|....                                      ||...||
Mouse   357 GFKANIVNEKCISQNSEMILKLLKMGNISWDVIPHHINLSAVTVEDYRLVYDIIQKVKEEEFAVL 421

  Fly   372 ---------------AGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTV 421
                           .|.|||||::.:|:..|...| .:|::||.||..||:||..|.:..|:|.
Mouse   422 HLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSMFGTIEGIITP 485

  Fly   422 LKDQFVNVKLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYG 486
            :.|.| .|:..|:.|...::.|.:|||::...|.:.:|:.|.:..|...|:..|.|.|||.::||
Mouse   486 IVDTF-KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYG 549

  Fly   487 TKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTM--RPLSYN-------GQEFPLV 542
            ..:..:|...||....|.||...|..::||::|.:|:.|::.|  .|..||       .:|| |.
Mouse   550 IDKFIEDLTDMLGFAPSKYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEF-LS 613

  Fly   543 YRVVGWCV 550
            |.:.|..|
Mouse   614 YPMWGMVV 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	178/544 (33%)
Slc6a15	NP_001239259.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..61		3/9 (33%)
Slc6a15	NP_001239259.1	SLC6sbd_SBAT1	61..640	CDD:212091	191/583 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4738
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.770