DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and Slc6a8

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_598748.1	Gene:	Slc6a8 / 102857	MGIID:	2147834	Length:	640	Species:	Mus musculus

Alignment Length:	576	Identity:	198/576 - (34%)
Similarity:	305/576 - (52%)	Gaps:	59/576 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |:.|...::|:|||:..:||||||||||:...:||||.|||||:::..|.|.||:::|:.||||.
Mouse    52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFM 116

  Fly   116 SRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG---- 176
            ..|.:.|::..||.:|:|||.::.:....|||..|:|....|...||.:.|||:.|...|.
Mouse   117 KAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDC 181

  Fly   177 ------DGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSG---SLALMLGI 232
                  :.|.:||.......||:...|...:.:..:::     .|..|:..|..   .:.|.|..
Mouse   182 VEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVL-----RLSTGLEVPGALNWEVTLCLLA 241

  Fly   233 SWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVW 297
            .|:.|...:.:||||:||..|..|.|||||:.:||||.:.||||.||::|:|.|.|.||..||||
Mouse   242 CWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVW 306

  Fly   298 YNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESG 362
            .:|.||:|||.|:..|.:....|||||.:|.|:||.|:..:::.||..:|.::|.|||.:|.|.|
Mouse   307 IDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQG 371

  Fly   363 TKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKD--- 424
            . .|:.|.::|||||||:||.|:....:.| :::.|||.||.:||:.|....|...:|.|.|
Mouse   372 V-HISKVAESGPGLAFIAYPRAVTLMPVAP-LWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLP 434

  Fly   425 --QFVNVKLWIIVVSLSVIGFLVGLIYIT-----PGGQHIITLMDFHGVTFVSLV-SAIFELIAV 481
              .:...:..|.|.....:.|::.|..:|     .||.::..|.|::..:..:|: .|.:|.:.|
Mouse   435 ASYYFRFQREISVALCCALCFVIDLSMVTDVSGGKGGMYVFQLFDYYSASGTTLLWQAFWECVVV 499

  Fly   482 GWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNG-QEFPLVYRV 545
            .|:||..|...|...|:..:...:.:.|||..||||.:.|.:::::...||.||. ..:|.....
Mouse   500 AWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEA 564

  Fly   546 VGW--------CVS----GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWG 589
            :||        ||.    ||::             :.||::..|..:..:|  .||
Mouse   565 MGWAFALSSMLCVPLHLLGCLL-------------RAKGTMAERWQHLTQP--IWG 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	180/497 (36%)
Slc6a8	NP_598748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
Slc6a8	NP_598748.1	SLC6sbd_CT1	52..626	CDD:271397	198/576 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820