Protein Alignment CG4476 and slc6a12

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_031754510.1
• Gene: slc6a12 / 100492029
• XenbaseID: XB-GENE-6033368
• Length: 612
• Species: Xenopus tropicalis
• Alignment Length: 594
• Identity: 217/594 - (36%)
• Similarity: 331/594 - (55%)
• Gaps: 44/594 - (7%)

  Fly    40 ESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPI 104
            |.....|:.:.|..|.:.:||::|.....:|||||||||:...:||||||.||||:.||..|.|:
 Frog    24 EGRHREPEIEDRGQWSNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPV 88

  Fly   105 YYMEMLLGQFSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPW 168
            :::|..|||::|:|.:..: ...||..|:|||..:..|.|..||..::|..|.|.|.||.:||||
 Frog    89 FFLETALGQYTSQGGITAWRKICPLFEGIGYASQVIEGYLNIYYIVILAWALFYLFSSFTAELPW 153

  Fly   169 SFCREEWG-DGCVSASGGQPLQGQLSRNF------SSSTQLYLQRIVLNETDSLEEGIGYPSGSL 226
            :.|...|. :.|:...|       .|.||      :||...:.:|.||:.::.:|. :|.....|
 Frog   154 ATCNNTWNTEHCIDFVG-------KSENFTSLENSTSSVVEFWERRVLHLSEGIEH-LGNVRWDL 210

  Fly   227 ALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKL 291
            ||.|.::|:.....|.:||||:||..|..|.||||::.|||||.:||||||:|::::|.|...:|
 Frog   211 ALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYVMLIILLVRGVTLPGAYEGIIFYLKPDMTRL 275

  Fly   292 LEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGN 356
            .:||||.:|.||:|||.|:|.|.:....|||::.:|.|||...:..|::.||.::|..||.:||.
 Frog   276 QDPQVWMDAGTQIFFSYAICQGCLTALGSYNKYNNNCYRDCIALCFLNSITSFVAGFAIFSVLGF 340

  Fly   357 LAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTV 421
            :|.|.|. .|:.|.::|||||||:||.|:....:.| ::|.|||.||..||:.|....|..::|.
 Frog   341 MAQEQGV-PISEVAESGPGLAFIAYPKAVTMMPVSP-LWSCLFFLMLIFLGLDSQFVCVESLVTA 403

  Fly   422 LKDQFVNV-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIA 480
            :.|.|.:|     :....:::::||.:|:|||.:|.||.::..|.|::..:...|: .||||:|.
 Frog   404 IVDMFPHVFRKKYRREFFILAVAVICYLLGLILLTEGGMYVFQLFDYYAASGTCLLFVAIFEVIC 468

  Fly   481 VGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQ-EFPLVYR 544
            ||::||..|...:.|.|:..:.....:.||...||.|.|...::||:...||.||.: .:|....
 Frog   469 VGYVYGANRFYDNIEDMIGYRPWPLVKYCWLFATPAVCLGTFLFSLIKYSPLKYNNRYVYPSWGY 533

  Fly   545 VVGWCVS----GCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSDWGPSDPKKLMDYQMFLRN 605
            .:||.::    .||....||     ...:.|||...|:...:.||:|.  ..|||.:
 Frog   534 AIGWLMALSSMICIPIYAFY-----IILRTKGSFTQRLKQLVTPHTDL--PQPKKYL-------- 583

  Fly   606 KDEENSKNV 614
            ||..:.|.:
 Frog   584 KDRADPKQI 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	188/487 (39%)
slc6a12	XP_031754510.1	SLC5-6-like_sbd	34..572	CDD:444915	206/552 (37%)