Protein Alignment CG4476 and slc6a3

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_002933174.1
• Gene: slc6a3 / 100488824
• XenbaseID: XB-GENE-982873
• Length: 621
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 206/605 - (34%)
• Similarity: 318/605 - (52%)
• Gaps: 60/605 - (9%)

  Fly    25 SGEALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAF 89
            :..||:.|         |:::.:...|:.|...::||:|.|..:|.|.||||||:...:||||||
 Frog    43 TNSALVSP---------SQINTENGERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAF 98

  Fly    90 LIPYLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALT 154
            |:||:..:.:.|.|::|||:.||||:..|...|:...|:.:||||..:|....:..:|..::|..
 Frog    99 LVPYIFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFKGVGYTVILISLYVGFFYNVIIAWA 163

  Fly   155 LRYFFDSFASELPWSFCREEWGD-GCVSASGGQPLQGQLSRNFSSSTQL-------------YLQ 205
            |:|.|.||.|||||..|...|.. .|....         ..|||..:..             |.:
 Frog   164 LQYLFSSFTSELPWIHCNNSWNSPNCSETK---------YSNFSDYSLFGLNDTYKVTPAAEYFE 219

  Fly   206 RIV--LNETDSLEEGIGYPSGSLALMLGISWLTVTLIII-----RGVKSSGKAAYVLALFPYVVM 263
            |.|  |:|:..:.: :|.|...|.     |.|.|.::.:     :|||:|||..::.|..||||:
 Frog   220 RGVLHLHESQGIHD-LGSPRWKLT-----SCLIVVIVFLYFSLWKGVKTSGKVVWITATMPYVVL 278

  Fly   264 FILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNV 328
            ..||:|.:|||||.||:..:|:..:.:|.|..||.:|.||:.|||.|.|||:|.:||||:|.:|.
 Frog   279 TALLLRGVTLPGAIDGIKAYLSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNC 343

  Fly   329 YRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQ 393
            ||||.|.|::::.||..||.:||..||.:|.:... .|..|.|.||||.||.||:|||...: ..
 Frog   344 YRDAIITTSVNSLTSFFSGFVIFSFLGYMAQKHNV-PIGDVAKDGPGLIFIIYPEAIATLPL-SS 406

  Fly   394 VFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNVK-------LWIIVVSLSVIGFLVGLIYIT 451
            |:|::||.||..||:.|.:|.:..::|.|.|:|..::       |:|::.:     |...|..:|
 Frog   407 VWSVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLRRHRELFTLFIVLCT-----FFTSLSCVT 466

  Fly   452 PGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPL 516
            .||.::.||:|........|...:.|.|.:.|.||..|...|.|.|:..:...|:|:||..|:|.
 Frog   467 NGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGKRPGLYWRLCWKFVSPC 531

  Fly   517 VMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNS 581
            .:|.::|.|::|.|...|....||....|:||.|:...:..:..:|.| .|....||.:.:|..:
 Frog   532 FLLFVVVVSIVTYRSPKYGNYTFPEWANVIGWLVAISSMAMVPLYAIY-KFSSLHGSFREKIAYA 595

  Fly   582 IKPHSDWGPSDPKKLMDYQM 601
            |.|..::...:..|:..:.:
 Frog   596 ITPEKEYELIESGKIRQFTL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	182/501 (36%)
slc6a3	XP_002933174.1	SLC6sbd_DAT1	60..615	CDD:212083	202/577 (35%)