Protein Alignment CG4476 and slc6a2

DIOPT Version :10

• Sequence 1: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_017948962.2
• Gene: slc6a2 / 100486589
• XenbaseID: XB-GENE-486549
• Length: 624
• Species: Xenopus tropicalis
• Alignment Length: 574
• Identity: 203/574 - (35%)
• Similarity: 324/574 - (56%)
• Gaps: 46/574 - (8%)

  Fly    43 ELSPD-------RKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVV 100
            :|||.       ::.|:.||..::||:|.:..||.|.|||||||...:||||||||||.:.|.:.
 Frog    48 DLSPQYEVPGEGQQEREQWGKKIDFLLSVVGFSVDLANVWRFPFLCYKNGGGAFLIPYTLFLIIA 112

  Fly   101 GKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASE 165
            |.|::|||:.|||::..|...|:...||.:||||..:|....:..||..::|.:|.|...||.||
 Frog   113 GMPLFYMELALGQYNREGAATVWKICPLFKGVGYTVILIALYVGFYYNVIIAWSLYYLVSSFTSE 177

  Fly   166 LPWSFCREEWGDGCVSASGGQPL---QGQLSRNFSSS-------TQLYLQRIV-LNETDSLEEGI 219
            |||..|..||.    |.:...|:   ...:|.|...|       .:.|.:.:: |:|::.:.: :
 Frog   178 LPWIKCGNEWN----SLNCTDPMLLNMSMISYNTKYSKFKTTPAAEFYERGVLHLHESNGIHD-L 237

  Fly   220 GYPSGSLALMLGISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFL 284
            |.|...|.:.|.:..:.:...:.:|||:|||..::.|..||||:|:||:|.:||||:..|:..:|
 Frog   238 GQPRWQLTICLIVVLIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIRGITLPGSSKGISAYL 302

  Fly   285 TPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVI 349
            ....::|.:..||.:|.||:|:||...|||:|.::|||:|.:|.||||.:.:|::..||.:||..
 Frog   303 HIDIKRLTDASVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALMTSTINCVTSFISGFA 367

  Fly   350 IFGILGNLAHESGTKDIASVVKAGPGLAFISYPDAIAKF--KMFPQVFSLLFFAMLFMLGVGSNV 412
            ||.|||.:||:... :|..|...|.||.||.||:||:..  ..|   ::::||.||..||:.|.:
 Frog   368 IFSILGYMAHKHNV-NIEDVATEGAGLVFIIYPEAISTLAGSTF---WAVVFFIMLLTLGIDSAM 428

  Fly   413 GMVSCIMTVLKDQFVNV-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV 472
            |.:..::|.|.|. :::     ||:.::|:.  |.|:..|:.||.||.:::||:|    ||.:..
 Frog   429 GGMEAVITGLADD-ISILKRHRKLFTLLVAF--ITFIFALLCITNGGIYVLTLLD----TFAAGT 486

  Fly   473 SAIF----ELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLS 533
            |.:|    |.|.|.|.||..|..:|...||..:...|:|:||..|:|..:|.:::.|::|.:||.
 Frog   487 SILFAVLIEAIGVSWFYGVDRFSEDIHRMLGFRPGLYWRLCWKFVSPAFLLFVVIVSIVTYKPLM 551

  Fly   534 YNGQEFPLVYRVVGWCVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSD 587
            |:..:||......||.::...:..:..:..| .|...:|||:.|:...|.|.::
 Frog   552 YDEYKFPPWANRTGWAIALSSMTLVPIYIIY-KFLTMRGSLRERLAYCITPENE 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	182/495 (37%)
slc6a2	XP_017948962.2	SLC5-6-like_sbd	63..622	CDD:444915	200/559 (36%)