DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and slc6a13

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_002667408.5	Gene:	slc6a13 / 100332592	ZFINID:	ZDB-GENE-170607-2	Length:	621	Species:	Danio rerio

Alignment Length:	563	Identity:	204/563 - (36%)
Similarity:	310/563 - (55%)	Gaps:	42/563 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 KARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQ 113
            |.|..|.:.|||::|.....:|||||||||:...:||||||.||||:.||..|.|::::|:.|||
Zfish    28 KDRGQWSNKLEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLEISLGQ 92

  Fly   114 FSSRGIVQVF-DFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG- 176
            ::|.|.:..: ..:||..|:|||..:.:.:|..||..|:|..:.|..:||...||||.|...|.
Zfish    93 YTSEGGITCWRKISPLFEGIGYATQVIVALLNFYYIIVLAWGIFYLSNSFTWNLPWSSCNNTWNT 157

  Fly   177 DGCVSASGGQPLQGQLSRNFSSSTQLYL-----------QRIVLNETDSLEEGIGYPSGSLALML 230
            :.|:          :..|...|..|.||           :|.||..:..:|: ||.....|.|.|
Zfish   158 ESCM----------EFQRRNDSVDQSYLDNATSPVIEFWERRVLRISSGIED-IGTLHWDLVLCL 211

  Fly   231 GISWLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQ 295
            .::|:.....|.:||||:||..|..|.||||::.|||:|.:|||||..|:.::|.|...:|.:||
Zfish   212 LLAWVLCYFCIWKGVKSTGKVVYFTATFPYVMLLILLIRGVTLPGASRGIQFYLYPDLGRLADPQ 276

  Fly   296 VWYNAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHE 360
            ||.:|.||:|||.|:|.|.:....|||::.:|.|||:..:..|::.||.::|..||.|||.:::|
Zfish   277 VWMDAGTQIFFSYAICLGCLTALGSYNKYNNNCYRDSLALCFLNSGTSFVAGFAIFSILGFMSYE 341

  Fly   361 SGTKDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQ 425
            ... .|:.|.::|||||||:||.|::...:.| :::..||.|:.:||:.|....|..::|.:.|.
Zfish   342 QNV-PISEVAESGPGLAFIAYPRAVSMMPISP-LWACFFFIMIVLLGLDSQFVCVESLVTAMVDM 404

  Fly   426 FVNV-------KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVG 482
            :.:.       :|.|:||  :::.||||||.:|.||.::..|.|::..:.:.|: .||||.:.:.
Zfish   405 YPSFFRRKNRRELLILVV--AIVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFETVCIA 467

  Fly   483 WIYGTKRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYNGQ-EFPLVYRVV 546
            ||||..|...:.|.|:..:...|.:.||...||........:||:...||.||.: .:|.....:
Zfish   468 WIYGANRFYDNIEDMIGYRPGPYIKYCWLFFTPATCFGTFAFSLIKYTPLKYNNEYVYPWWGYAL 532

  Fly   547 GW--CVSGCIIGQLFYWAGYANFKQPKGSLKSRINNSIKPHSD 587
            ||  .:|..|...|  |..| .....||||..|:...|:|..|
Zfish   533 GWMLALSSMICVPL--WVIY-RMGTTKGSLMERVQFLIRPSPD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	180/494 (36%)
slc6a13	XP_002667408.5	SLC6sbd-TauT-like	30..569	CDD:271387	201/556 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820