DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4476 and slc6a14

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	555	Identity:	206/555 - (37%)
Similarity:	323/555 - (58%)	Gaps:	28/555 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |.||.|..|:::|.|..:||||||||||:.|.::|||||||||.::|.|.|.|:::||...|||.
Zfish    42 RGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLAVSGLPLFFMESSFGQFC 106

  Fly   116 SRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSF--CR---EEW 175
            |:|.:.|:...|:::|||...:|....:|.||..::|.::.|.|.||...||||.  |.   ...
Zfish   107 SQGPINVWKAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQDPLPWSIKNCNTTASNI 171

  Fly   176 GDGCVSASGGQPLQGQLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPSGSLALMLGISWLTVTLI 240
            ....|:.|.|| :.||      |.::.|...:.|..:.|::| .|.....|||.|.:||:.|...
Zfish   172 STAAVNVSCGQ-ISGQ------SLSEKYWDEVALQRSSSMDE-TGPVVWHLALCLLLSWILVGAA 228

  Fly   241 IIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQ--WEKLLEPQVWYNAVTQ 303
            :.:|:|||||..|..|.|||:|:.|||:|..||.||.||:.:::..|  ..||.|.:||.:|.||
Zfish   229 LFKGIKSSGKVVYFTATFPYIVLLILLIRGATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQ 293

  Fly   304 VFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIAS 368
            :||||::.:|.::..||||:|.:|.|:|:.:|...:..||:.:|..||.:||::||.. .:.::.
Zfish   294 IFFSLSIAWGGLMALSSYNKFYNNCYQDSIVVCVTNCGTSIFAGFAIFSVLGHMAHVY-QRPVSE 357

  Fly   369 VVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVNV---K 430
            |..||..||||:||||::|..:.| ::|:|||.||..||:.|....:..|.|.|.|.:..|   |
Zfish   358 VADAGFALAFIAYPDALSKLPISP-LWSILFFFMLITLGLDSQFAGIEVISTCLLDAYPEVLKSK 421

  Fly   431 LWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAE 495
            ..::..::.:|.||:||..:|..|.:.:.|:|.....::.||:.:.|::.:..:||..|..:|.|
Zfish   422 RGLVTTAVCIILFLLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLEVLGLCILYGGNRFIKDIE 486

  Fly   496 YMLNIKTSNY---YRICWSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQ 557
            .|:..|:|.:   :|.||..:||:|:.:||::||.|....:|:...:|.....:|||::..   .
Zfish   487 MMIGTKSSLFWLWWRACWFFITPVVLSIILIWSLYTFTSPTYSSVAYPDWGISLGWCITAF---S 548

  Fly   558 LFYWAGYANFK--QPKGSLKSRINNSIKPHSDWGP 590
            |.:....|.:|  :.:|.|..||.::..|..||||
Zfish   549 LMWIPIVAVWKVCKARGGLWQRIKSACSPTEDWGP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	185/486 (38%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	206/555 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920