DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4476 and si:ch211-132b12.1

DIOPT Version :9

Sequence 1:	NP_648293.1	Gene:	CG4476 / 39056	FlyBaseID:	FBgn0035969	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001076533.1	Gene:	si:ch211-132b12.1 / 100034467	ZFINID:	ZDB-GENE-050420-315	Length:	586	Species:	Danio rerio

Alignment Length:	554	Identity:	197/554 - (35%)
Similarity:	305/554 - (55%)	Gaps:	48/554 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIPYLVVLFVVGKPIYYMEMLLGQFS 115
            |..|||.:|||::.....||||||||||:...:.|||||||||||.:...|.|::.:||.:||::
Zfish    11 RGYWGSKMEFLLAVAGNVVGLGNVWRFPYLCYKYGGGAFLIPYLVFVVTCGVPLFLLEMAMGQYT 75

  Fly   116 SRGIVQVFD-FAPLMRGVGYAQLLALGVLATYYASVMALTLRYFFDSFASELPWSFCREEWG-DG 178
            .:|.|..:. ..||..|:||...|.|.....||..::|..|.|...||.|:|||:.|...|. |.
Zfish    76 QQGGVTCWHRLCPLAEGIGYGGQLILLYSCMYYIVILAWALFYLIFSFKSQLPWATCDNTWNTDD 140

  Fly   179 CVSASGGQPLQGQLSRNFS-SSTQL---------YLQRIVLNETDSLEEGIGYPSGSLALMLGIS 233
            |::.         :::|.: :.|.|         :.:|.||:.:..:|: ||..:..:.|.|...
Zfish   141 CINL---------VTKNLTINRTSLINSTPAATEFWERRVLSLSGGIED-IGKINWEILLCLIAM 195

  Fly   234 WLTVTLIIIRGVKSSGKAAYVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWY 298
            |:.....:.:||||:||..|..|.||||::.:||:|.||||||..||:::|.|:..:|.:||||.
Zfish   196 WIICYFCVWKGVKSTGKVVYFTATFPYVMLLVLLIRGLTLPGALQGVVFYLYPEPARLADPQVWL 260

  Fly   299 NAVTQVFFSLAVCFGVIIMYSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGT 363
            .|.||:.||.:|..|.|.:.:|||::.:|.|||...:..|::.||.::|..:|.:||.:|.|.|.
Zfish   261 EAGTQILFSYSVSVGSITVLASYNKYHNNCYRDCLGLCLLNSVTSFVAGFAVFTVLGFMAQEQGV 325

  Fly   364 KDIASVVKAGPGLAFISYPDAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQFVN 428
             .|..|.::|||||||:||.|:|... |||::::.||.|:.:||:.:....:..::|.:.|.|..
Zfish   326 -PIEEVAESGPGLAFIAYPQAVAMMP-FPQLWAVCFFIMIILLGLDTQFVSMEAVVTSVMDMFPV 388

  Fly   429 V-----KLWIIVVSLSVIGFLVGLIYITPGGQHIITLMDFHGVTFVSLV-SAIFELIAVGWIYGT 487
            |     :..|:::...:..|....|.:|.||.::..|.|::......|: .::||.:.:|||:|.
Zfish   389 VLRREGRREILLLFFCLTCFFGQFIMVTEGGMYVFQLFDYYACNGTCLLFLSVFESLTMGWIFGA 453

  Fly   488 KRLCQDAEYMLNIKTSNYYRICWSIVTPLVMLVILVYSLLTMRPLSYN-GQEFPLVYRVVGW--- 548
            .||....|.|...:.:..:.:||..:||||.||..|.|::..:||::| ...||....|:||
Zfish   454 DRLFDIIEDMTKSRPNYIFMLCWKYLTPLVSLVCFVCSMVEYQPLTFNRWYVFPDWAYVLGWLLA 518

  Fly   549 -----CVSGCIIGQLFYWAGYANFKQPKGSLKSR 577
                 .|.|..:|:|.         ..|||||.|
Zfish   519 LSSIVLVPGWALGRLC---------SEKGSLKQR 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	177/491 (36%)
si:ch211-132b12.1	NP_001076533.1	SLC6sbd-TauT-like	11..549	CDD:271387	197/554 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820