DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc45-1 and SLC45A4

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001273575.1	Gene:	SLC45A4 / 57210	HGNCID:	29196	Length:	808	Species:	Homo sapiens

Alignment Length:	703	Identity:	186/703 - (26%)
Similarity:	294/703 - (41%)	Gaps:	204/703 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 AIAMAIEFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLRWGRRRP 121
            |:....||.||.||:.|:|||||||:..::.|:||.|||::|...:||:||.||||.|.||||||
Human    57 AVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRP 121

  Fly   122 IISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGSVAALVSGEATTGPSASDY 186
            .|..|..|::.|:.|...|..:||.|||.                              |:..
Human   122 FILALCVGVLFGVALFLNGSAIGLALGDV------------------------------PNRQ-- 154

  Fly   187 KFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAIGGVDWE 251
            ...::||:||:|:|||.||..:.|.|.||||:...|||..|:.:.|..||.||.|||.:||:||.
Human   155 PIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWT 219

  Fly   252 TTHIGSFMGGNIPTVFTLVTIIFAVCYLI------------------------------------ 280
            .|.:||:.......:|....|||.|...:
Human   220 QTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFP 284

  Fly   281 -TVTTFREIPLPLIEQD---------------------ELL-------------------RPLSE 304
             .|.:..|:.|...:.|                     |||                   |..|:
Human   285 DEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQ 349

  Fly   305 QAIK----------KELKKKNNTIY--YIQETTQLELQMASDDPKRLEALQG------------- 344
            :..|          ||..|::.|:.  ::.|.   ::...|..|.: :||.|
Human   350 ELAKTKLPRLATFLKEAAKEDETLLDNHLNEA---KVPNGSGSPTK-DALGGYTRVDTKPSATSS 410

  Fly   345 ----------------------------SYQNGYSPAVEKQGKS-QDL----------------- 363
                                        .|:...:..:.|..:| .||
Human   411 SMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSG 475

  Fly   364 ------ETQSDY-DAPVSLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHG 421
                  :|:|:. :...:::....|:..||..:..|.|.:|..|...:...:::|||:|:.:|.|
Human   476 ATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEG 540

  Fly   422 DPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWF--GTKAVYISGMIYYGIGM 484
            ||.|..||.|...|.|||:.||||:.|||.:.:|.|..:.|.:..:  ..:.:|:.|.:.:.:|.
Human   541 DPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGT 605

  Fly   485 LVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQARGLGTD 546
            .|:.::|..:..:|..::.||:..:|...|:.|:.:||     .||  :.:   |....||.|.|
Human   606 AVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYH-----DIK--QYIHHSPGNSKRGFGID 663

  Fly   547 VAIISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYASTFLSFLAAIAAMF-VLY 598
            .||:|..|:|:|::|:.::|.:|..:.|...:...::..|||..:.|.| |:|
Human   664 CAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIY 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	177/670 (26%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	43/158 (27%)
SLC45A4	NP_001273575.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		MFS	52..>251	CDD:119392	89/225 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..284		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..419		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..489		2/28 (7%)
		MFS	518..>714	CDD:119392	62/202 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69908
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5076
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890