Protein Alignment Slc45-1 and SLC45A1

DIOPT Version :9

• Sequence 1: NP_001261618.1
• Gene: Slc45-1 / 39055
• FlyBaseID: FBgn0035968
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001366543.1
• Gene: SLC45A1 / 50651
• HGNCID: 17939
• Length: 756
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 191/706 - (27%)
• Similarity: 315/706 - (44%)
• Gaps: 188/706 - (26%)

  Fly    39 DYSHVFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSP 103
            |:..:..:::..|:.....|...|||:||.||::|:|:|||:|:..:..|:.|.:||::||.:.|
Human    74 DFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQP 138

  Fly   104 LLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGS 168
            |||:.||||..|:|||||.|.:|:.|.:.||.|:..|:|:|:.|.|
Human   139 LLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGIALAD------------------- 184

  Fly   169 VAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFAL 233
                     .||    ::|:.::||:.|:||:||.||:...|:..|::|:|.|.:|.:.:.:.||
Human   185 ---------VTG----NHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDRGLNIHAL 236

  Fly   234 FAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTTFRE----------- 287
            .||.||..||.:||:.|:.|..|..:||.:..::....:..:|..::|:.:..|
Human   237 LAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEKRA 301

  Fly   288 ------IPLP---------------------------------------LIEQDELLRPLSE--- 304
                  :|||                                       .|.:|..|..:||
Human   302 AMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFAS 366

  Fly   305 ----------------------QAIKKELKKKNNTI--------YYIQETTQLE----------- 328
                                  .||...:.:...::        :|.|:...||
Human   367 SFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCD 431

  Fly   329 ---LQMASDD------------PKRL---EALQG-------------SYQ------NGYSPAVEK 356
               |::.|.|            |:.|   :|..|             |.|      ||.....|.
Human   432 GDILRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESEL 496

  Fly   357 QGKSQDLETQSDYDAPVSLKAYLKSIFIMPYSMRMLALTNLF--------CWMGHVTYCLYFTDF 413
            .|.|:..|      .|:|:.....:|..||.::|.|.:.:..        .|:......|::|||
Human   497 TGSSERAE------QPLSVGRLCSTICNMPKALRTLCVNHFLGELPAKPPRWLSFEGMLLFYTDF 555

  Fly   414 VGEAVFHGDPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMI 478
            :||.||.|||.|...|||...|.:||..|||||.|||||.:.||..:.||.::...:.:|....:
Human   556 MGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYL 620

  Fly   479 YYGIGMLVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGEIVPLKQARGL 543
            .:|:|..:..|....:.||....:.|||:.|:.|:|:.|:..|:....|:..:.:    ...||:
Human   621 AFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSAD----GTRRGM 681

  Fly   544 GTDVAIISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYASTFLSFLAAI-AAMFVLY 598
            |.|::::|...|:||::|||.:|||.|.:.:...|:|.|:.:|||..: :::||:|
Human   682 GVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIY 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	178/663 (27%)
		MFS	444..>597	CDD:119392	49/153 (32%)
SLC45A1	NP_001366543.1	MFS	87..730	CDD:421695	186/684 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159269
Domainoid	1	1.000	153	1.000	Domainoid score	I4286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2248
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5076
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.040