Protein Alignment Slc45-1 and SLC45A1

DIOPT Version :10

• Sequence 1: NP_648292.1
• Gene: Slc45-1 / 39055
• FlyBaseID: FBgn0035968
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001366543.1
• Gene: SLC45A1 / 50651
• HGNCID: 17939
• Length: 756
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 191/706 - (27%)
• Similarity: 315/706 - (44%)
• Gaps: 188/706 - (26%)

  Fly    39 DYSHVFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSP 103
            |:..:..:::..|:.....|...|||:||.||::|:|:|||:|:..:..|:.|.:||::||.:.|
Human    74 DFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQP 138

  Fly   104 LLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGS 168
            |||:.||||..|:|||||.|.:|:.|.:.||.|:..|:|:|:.|.|
Human   139 LLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGIALAD------------------- 184

  Fly   169 VAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFAL 233
                     .||    ::|:.::||:.|:||:||.||:...|:..|::|:|.|.:|.:.:.:.||
Human   185 ---------VTG----NHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDRGLNIHAL 236

  Fly   234 FAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTTFRE----------- 287
            .||.||..||.:||:.|:.|..|..:||.:..::....:..:|..::|:.:..|
Human   237 LAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSIPERPLRPPSEKRA 301

  Fly   288 ------IPLP---------------------------------------LIEQDELLRPLSE--- 304
                  :|||                                       .|.:|..|..:||
Human   302 AMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKYGSFISRDSSLTGISEFAS 366

  Fly   305 ----------------------QAIKKELKKKNNTI--------YYIQETTQLE----------- 328
                                  .||...:.:...::        :|.|:...||
Human   367 SFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPISVSFPRAPDGFYRQDRGLLEGREGALTSGCD 431

  Fly   329 ---LQMASDD------------PKRL---EALQG-------------SYQ------NGYSPAVEK 356
               |::.|.|            |:.|   :|..|             |.|      ||.....|.
Human   432 GDILRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVANILLNGVKYESEL 496

  Fly   357 QGKSQDLETQSDYDAPVSLKAYLKSIFIMPYSMRMLALTNLF--------CWMGHVTYCLYFTDF 413
            .|.|:..|      .|:|:.....:|..||.::|.|.:.:..        .|:......|::|||
Human   497 TGSSERAE------QPLSVGRLCSTICNMPKALRTLCVNHFLGELPAKPPRWLSFEGMLLFYTDF 555

  Fly   414 VGEAVFHGDPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMI 478
            :||.||.|||.|...|||...|.:||..|||||.|||||.:.||..:.||.::...:.:|....:
Human   556 MGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYL 620

  Fly   479 YYGIGMLVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGEIVPLKQARGL 543
            .:|:|..:..|....:.||....:.|||:.|:.|:|:.|:..|:....|:..:.:    ...||:
Human   621 AFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSAD----GTRRGM 681

  Fly   544 GTDVAIISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYASTFLSFLAAI-AAMFVLY 598
            |.|::::|...|:||::|||.:|||.|.:.:...|:|.|:.:|||..: :::||:|
Human   682 GVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLFVIY 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_648292.1	MFS_SLC45_SUC	52..591	CDD:340871	186/683 (27%)
SLC45A1	NP_001366543.1	MFS	87..730	CDD:475125	186/684 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..339		3/44 (7%)