DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc45-1 and slc45a2

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001011335.1	Gene:	slc45a2 / 496798	XenbaseID:	XB-GENE-947685	Length:	549	Species:	Xenopus tropicalis

Alignment Length:	612	Identity:	188/612 - (30%)
Similarity:	300/612 - (49%)	Gaps:	99/612 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VRNPMIKYMLKTRENHAREQDRDYS--------HVF------RRKTRFEMFRLSAIAMAI---EF 64
            |..|..:..|.:...:...:|.::|        .||      ||.|.    ||...:||:   ||
Frog     7 VEYPAPQKQLSSTGLYPSTKDMEFSASLEQMNGEVFQAVEPPRRSTG----RLIMHSMAMFGREF 67

  Fly    65 AYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFG 129
            .||.|.:||:|:||.:|:.....|:.|.:||::||.:.|::||.||.|:.|||||||.|..|
Frog    68 CYAVEAAFVTPVLLSVGLPRSLYSLVWLISPILGFILQPVVGSASDYCRSRWGRRRPYILCL--- 129

  Fly   130 IMCGLILVPYGKDLGLLL---GDAGYTYAESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVI 191
               |:|:|     ||:.|   ||...|                       |..|.|.....:|::
Frog   130 ---GIIMV-----LGMTLYLNGDTAVT-----------------------AVLGTSPEKTTWAIV 163

  Fly   192 LTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIG 256
            :|:||:|..||.||....|.:.||.|:|...::.:.:...|||.|.||.:||..|.:||.:|.:|
Frog   164 ITMLGVVAFDFAADFIDGPIKAYLFDVCSHHDKERGLHYHALFTGLGGALGYLTGAMDWGSTFLG 228

  Fly   257 SFMGGNIPTVFTLVTIIFAVCYLITVTTFREIPLPLIEQDELLRPLSEQAIKKE-------LKKK 314
            ..||.....:|...:.:|.:...:.:.:..||||    :||  :..::..:|.:       :.|.
Frog   229 RIMGSEFQVMFFFASSVFLIFLAVHLCSIPEIPL----EDE--KQETQMLLKHDHLGAYGSIDKA 287

  Fly   315 NNTIYYIQETTQLELQMASDDPKRLEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPVSLKAYL 379
            .|.|...::|::...|:..::|           |.....|:|:               :::|:.:
Frog   288 QNGILKNRKTSRSLSQVEENNP-----------NDREEQVQKR---------------MTVKSLI 326

  Fly   380 KSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAGVRFGCW 444
            .::|.||...|.|.|::|..|...::..|:||||:|:.|:||:|.|..||.|.|.||.||..|||
Frog   327 SALFTMPAHYRYLCLSHLIGWTAFLSNMLFFTDFMGQIVYHGNPYAEHNSTAYLTYERGVEVGCW 391

  Fly   445 GMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFSTSAGILYGT 509
            ||.|.|.|.::||.....|:.:.|.|.:|..|.:.:|:|...:||:|..:..||..:..|::..|
Frog   392 GMCINAISSALYSYIQKALLPYIGLKGLYFLGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSST 456

  Fly   510 IFTVPFILVARYHAKNCFSIK-NGEIVPLKQARGLGTDVAIISSMVFIAQLIVSLSVGPLVSWMD 573
            ::||||.|::.||.:.....: ||:.......||.|.|.|.::.||.:||:||...:|.|||...
Frog   457 LYTVPFNLISEYHREEEQETQPNGKTPTPSDNRGKGIDCAALTCMVQLAQIIVGGGLGFLVSLAG 521

  Fly   574 TTCAVLYASTFLSFL-AAIAAMFVLYV 599
            :...|:.:::..|.: ....|:||.||
Frog   522 SVVVVVISASAASLIGCCFVALFVRYV 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	168/532 (32%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	50/154 (32%)
slc45a2	NP_001011335.1	GPH_sucrose	47..468	CDD:273545	155/490 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2983
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2668
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	1	1.000	-	-		otm47530
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5076
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.110