Protein Alignment Slc45-1 and Slc45a4

DIOPT Version :10

• Sequence 1: NP_648292.1
• Gene: Slc45-1 / 39055
• FlyBaseID: FBgn0035968
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: XP_006241803.1
• Gene: Slc45a4 / 315054
• RGDID: 1309971
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 751
• Identity: 187/751 - (24%)
• Similarity: 300/751 - (39%)
• Gaps: 223/751 - (29%)

  Fly    27 KTRENHAREQDRDYSH--VFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSM 89
            |.|:..|..|:...|.  :.|..||..:.. .|:....||.||.||:.|:|||||||:..|:.|:
  Rat    27 KPRDPAAETQEETTSEASIDRIPTRLWVMH-GAVMFGREFCYAMETALVTPILLQIGLPEKYYSL 90

  Fly    90 TWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTY 154
            ||.|||::|...:||:||.||||.|.||||||.|.:|..|::.|:.|...|..:||.|||.
  Rat    91 TWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILVLCVGVLIGVALFLNGSAIGLALGDV---- 151

  Fly   155 AESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMC 219
                                      ||..  ...::||:||:|:|||.||..:.|.|.||||:.
  Rat   152 --------------------------PSRQ--PIGIVLTVLGVVVLDFSADATEGPIRAYLLDVV 188

  Fly   220 VPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTT 284
            ..|||..|:.:.|..||.||.|||.:||:||..|.:|.:.......:|....:.|:|...:.:.:
  Rat   189 DSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVFFSVSVALHLFS 253

  Fly   285 FRE--------------------------IPLPLI------------------------------ 293
            ..|                          .|.|.:
  Rat   254 IEEEQYNPQQDRGPEDATLPSTGLQPGAPAPAPRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLD 318

  Fly   294 ------EQDELLR----------------------------PLSEQAIKKEL--KKKNNTIYYIQ 322
                  :.|.:|.                            |.:.|:..:||  .|......:::
  Rat   319 VDIVRSKSDSVLHMADSTLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLR 383

  Fly   323 ETTQ---------------------------------LELQMASDDPKR---------------- 338
            |:|:                                 |:..:.|...:|
  Rat   384 ESTKEDDTLLDNHLNEAKVPNGRGSPPMNPLSHSKVDLKPSVTSSSMRRRRHMFHRQSSSTFSYY 448

  Fly   339 ------------------------------LEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPV 373
                                          |:..|.|.....|.|....|.::..|.:::    .
  Rat   449 GKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETE----T 509

  Fly   374 SLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAG 438
            :::....|:..||..:..|.|.:|..|...:...:::|||:|:.:|.|:|.|..||.....|.||
  Rat   510 TVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAG 574

  Fly   439 VRFGCWGMAIYAFSCSIYSLSVTKLMKWF--GTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFST 501
            |:.||||:.|||.:.:|.|..:.|.:..:  ..:.:|:.|.:.:.:|..|:.::|..:..:|..:
  Rat   575 VKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTIS 639

  Fly   502 SAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQARGLGTDVAIISSMVFIAQLIVSL 563
            :.|::..:|...|:.|:..||     .||  |.|   |....||.|.|.||:|..|:|:|::|:.
  Rat   640 TMGVVSMSISYCPYALLGHYH-----DIK--EYVHHSPGNSKRGFGIDCAILSCQVYISQILVAS 697

  Fly   564 SVGPLVSWMDTTCAVLYASTFLSFLAAIAAMF-VLY 598
            ::|.:|..::|...:...::..|||..:.|.| |:|
  Rat   698 ALGGVVDTVNTIVVIPIVASVGSFLGFLTATFLVIY 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_648292.1	MFS_SLC45_SUC	52..591	CDD:340871	175/714 (25%)
Slc45a4	XP_006241803.1	MFS	53..>275	CDD:475125	89/254 (35%)
		MFS	<514..726	CDD:475125	65/218 (30%)