DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc45-1 and Slc45a4

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	XP_006241803.1	Gene:	Slc45a4 / 315054	RGDID:	1309971	Length:	785	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	187/751 - (24%)
Similarity:	300/751 - (39%)	Gaps:	223/751 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KTRENHAREQDRDYSH--VFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSM 89
            |.|:..|..|:...|.  :.|..||..:.. .|:....||.||.||:.|:|||||||:..|:.|:
  Rat    27 KPRDPAAETQEETTSEASIDRIPTRLWVMH-GAVMFGREFCYAMETALVTPILLQIGLPEKYYSL 90

  Fly    90 TWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTY 154
            ||.|||::|...:||:||.||||.|.||||||.|.:|..|::.|:.|...|..:||.|||.
  Rat    91 TWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILVLCVGVLIGVALFLNGSAIGLALGDV---- 151

  Fly   155 AESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMC 219
                                      ||..  ...::||:||:|:|||.||..:.|.|.||||:.
  Rat   152 --------------------------PSRQ--PIGIVLTVLGVVVLDFSADATEGPIRAYLLDVV 188

  Fly   220 VPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTT 284
            ..|||..|:.:.|..||.||.|||.:||:||..|.:|.:.......:|....:.|:|...:.:.:
  Rat   189 DSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVFFSVSVALHLFS 253

  Fly   285 FRE--------------------------IPLPLI------------------------------ 293
            ..|                          .|.|.:
  Rat   254 IEEEQYNPQQDRGPEDATLPSTGLQPGAPAPAPRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLD 318

  Fly   294 ------EQDELLR----------------------------PLSEQAIKKEL--KKKNNTIYYIQ 322
                  :.|.:|.                            |.:.|:..:||  .|......:::
  Rat   319 VDIVRSKSDSVLHMADSTLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLR 383

  Fly   323 ETTQ---------------------------------LELQMASDDPKR---------------- 338
            |:|:                                 |:..:.|...:|
  Rat   384 ESTKEDDTLLDNHLNEAKVPNGRGSPPMNPLSHSKVDLKPSVTSSSMRRRRHMFHRQSSSTFSYY 448

  Fly   339 ------------------------------LEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPV 373
                                          |:..|.|.....|.|....|.::..|.:::    .
  Rat   449 GKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETE----T 509

  Fly   374 SLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAG 438
            :::....|:..||..:..|.|.:|..|...:...:::|||:|:.:|.|:|.|..||.....|.||
  Rat   510 TVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAG 574

  Fly   439 VRFGCWGMAIYAFSCSIYSLSVTKLMKWF--GTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFST 501
            |:.||||:.|||.:.:|.|..:.|.:..:  ..:.:|:.|.:.:.:|..|:.::|..:..:|..:
  Rat   575 VKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTIS 639

  Fly   502 SAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQARGLGTDVAIISSMVFIAQLIVSL 563
            :.|::..:|...|:.|:..||     .||  |.|   |....||.|.|.||:|..|:|:|::|:.
  Rat   640 TMGVVSMSISYCPYALLGHYH-----DIK--EYVHHSPGNSKRGFGIDCAILSCQVYISQILVAS 697

  Fly   564 SVGPLVSWMDTTCAVLYASTFLSFLAAIAAMF-VLY 598
            ::|.:|..::|...:...::..|||..:.|.| |:|
  Rat   698 ALGGVVDTVNTIVVIPIVASVGSFLGFLTATFLVIY 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	171/694 (25%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	44/158 (28%)
Slc45a4	XP_006241803.1	MFS	53..>275	CDD:421695	89/254 (35%)
Slc45a4	XP_006241803.1	MFS	<514..726	CDD:421695	65/218 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69908
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860