DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc45-1 and Slc45a2

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001101123.1	Gene:	Slc45a2 / 310152	RGDID:	1306690	Length:	530	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	174/556 - (31%)
Similarity:	285/556 - (51%)	Gaps:	70/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RLSAIAMAI---EFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLR 115
            ||...:||:   ||.||.|.::|:|:||.:|:.....||.|.|||::||.:.|::||.||.|:.|
  Rat    34 RLVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRAR 98

  Fly   116 WGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGSVAALVSGEATTG 180
            ||||||.  ||:.|:|             :|||.|.|...::|          |:|||:.
  Rat    99 WGRRRPY--ILTLGVM-------------MLLGMALYLNGDAA----------VSALVAN----- 133

  Fly   181 PSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAI 245
             ......:|:.:|::|:||.||.||....|.:.||.|:|..:::.|.:...|||.||||.:||.:
  Rat   134 -PRQKLVWAISITMIGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYLL 197

  Fly   246 GGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTTFREIPLPLIEQDELLRPLSEQAIKKE 310
            |.:||....:|..:|.....:|....::..:|::..:.:..|.||.....|..|:|..:.:
  Rat   198 GAIDWMHLELGKLLGTEFQVMFFFSALVLTLCFITHLCSIPEDPLRDDATDPPLQPDPQGS---- 258

  Fly   311 LKKKNNTIYYIQETTQLELQMASDDPKRLEALQGSYQNGYS----PAVEKQGKSQDLETQSDYDA 371
                               .:::|...|..::: ..:||.:    |.  :.||::....||  ..
  Rat   259 -------------------SLSADGMPRYGSIE-KVKNGDADTGLPV--QGGKNKKPSGQS--QR 299

  Fly   372 PVSLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYE 436
            .:|:|:.|:::..||...|.|.:::|..|...::..|:||||:|:.|:||||..|.||...|.||
  Rat   300 TMSMKSLLRALVNMPSHYRCLCISHLIGWTAFLSNMLFFTDFMGQIVYHGDPYGAHNSTEFLIYE 364

  Fly   437 AGVRFGCWGMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFST 501
            .||..||||:.|.:...|:||.....::.:.|.|.:|..|.:.:|:|...:||:|..:..||..:
  Rat   365 RGVEVGCWGLCINSVFSSVYSYFQKVMVSYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCS 429

  Fly   502 SAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV--PLKQARGLGTDVAIISSMVFIAQLIVSLS 564
            ..|::..|::||||.|:|.||.:. ...|..|:.  |....||.|.|.|.::.||.:||::|...
  Rat   430 MFGVMSSTLYTVPFNLIAEYHREE-EKEKQQEVPGGPDNHGRGKGVDCAALTCMVQLAQILVGGG 493

  Fly   565 VGPLVSWMDTTCAVLYASTFLSFL-AAIAAMFVLYV 599
            :|.||:...:...|:..::.::.: ....|:||.||
  Rat   494 LGFLVNMAGSVVVVVITASAVALIGCCFVALFVRYV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	166/522 (32%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	46/155 (30%)
Slc45a2	NP_001101123.1	MFS_2	36..524	CDD:290085	167/547 (31%)
Slc45a2	NP_001101123.1	MFS	<39..231	CDD:304372	78/222 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	1	1.000	-	-		otm44490
orthoMCL	1	0.900	-	-		OOG6_100660
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760