DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc45-1 and lovit

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001303415.1	Gene:	lovit / 26067050	FlyBaseID:	FBgn0267429	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	267/601 - (44%)
Similarity:	369/601 - (61%)	Gaps:	54/601 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LKTRENHAREQDRDYSHVFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSMT 90
            :|...|.....::|:|||||.|||.|:.|:||..|.|||:|||||:||||.||:|||:|:||::.
  Fly    40 VKKHLNGNTSANKDFSHVFRTKTRTELVRVSAAVMGIEFSYAAETAFVSPTLLKIGVEHQHMTLV 104

  Fly    91 WGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAG---- 151
            |.||||:|||:.|:|||:||||||..|||||.|.:||.|::.||:|||.|:.||..|||..
  Fly   105 WALSPLVGFFLCPILGSLSDRCKLNIGRRRPFILLLSIGVIFGLLLVPNGEALGYWLGDDNLQSL 169

  Fly   152 --YTYAESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTY 214
              ::...:..|.||             ....||.|.:.:.:..|:||.||||||||.||:|||.|
  Fly   170 DMFSEINNLKNITS-------------IYNSPSQSSHSWGIFFTVLGTVLLDFDADACQSPARAY 221

  Fly   215 LLDMCVPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYL 279
            |||:|:||:|.:.::.|.:.||.||..||::|||:|:.|.||..:||::..||:::||||..|..
  Fly   222 LLDVCLPEDQARGLSTFTIMAGLGGFFGYSMGGVNWDETEIGRRLGGHVKAVFSIITIIFIACVT 286

  Fly   280 ITVTTFREIPLPLIEQDELLRPLSEQAIKK---ELKKKNNTIYYIQETTQLELQMASDDP----- 336
            .|:|:|.||||.::...:......|.|:.|   .....:.||....|..|::.:  .::|
  Fly   287 FTLTSFAEIPLWVLANTDTKNCGGETALSKSYGSCDSHDKTINCTDENKQVKTE--DENPNISIA 349

  Fly   337 ----------KRLEALQ--GSYQNGYSPAVEKQGKSQDLETQSDYDAPVSLKAYLKSIFIMPYSM 389
                      :..|.:|  |..|||     :.......:|.:       ||..||.||..||.|:
  Fly   350 YRIVDETSFTENSEIIQENGCTQNG-----DSYNAQNTMEVE-------SLSHYLLSIVYMPLSL 402

  Fly   390 RMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCS 454
            :::.:|||||||.||.|.||||||||||||.|||.|...|.....||.||||||||||:|:.|||
  Fly   403 KLICVTNLFCWMAHVCYSLYFTDFVGEAVFKGDPKATLGSLPQKRYEEGVRFGCWGMAMYSLSCS 467

  Fly   455 IYSLSVTKLMKWFGTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVA 519
            .|||.:..|::.|..|.||:.|::.|.|||.::.|...|..|:|||.:|||:|.|:||:|::|||
  Fly   468 FYSLVIEYLIQRFRAKTVYVGGLLVYCIGMALMALTRAKLSVIVFSWTAGIMYSTLFTMPYLLVA 532

  Fly   520 RYHAKNCFSIKNGEIVPLKQA-RGLGTDVAIISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYAST 583
            .||..:.|.:.|.....|... |||||||||||||||:||.::||.:|.::....||.||:..::
  Fly   533 HYHNVSTFELDNNGAAKLGSGLRGLGTDVAIISSMVFLAQFLLSLCMGTIIKISGTTTAVISTAS 597

  Fly   584 FLSFLAAIAAMFVLYV 599
            ||||..|::|..::|:
  Fly   598 FLSFCGALSATRIMYL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	246/545 (45%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	73/153 (48%)
lovit	NP_001303415.1	GPH_sucrose	66..580	CDD:273545	243/540 (45%)
		MFS	<66..289	CDD:304372	115/235 (49%)
		MFS	<392..607	CDD:119392	113/214 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469338
Domainoid	1	1.000	87	1.000	Domainoid score	I2739
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1689
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	1	1.000	-	-		otm26412
orthoMCL	1	0.900	-	-		OOG6_100660
Panther	1	1.100	-	-	P	PTHR19432
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X285
	11	10.910