Protein Alignment Slc45-1 and Slc45a2

DIOPT Version :9

• Sequence 1: NP_001261618.1
• Gene: Slc45-1 / 39055
• FlyBaseID: FBgn0035968
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_444307.1
• Gene: Slc45a2 / 22293
• MGIID: 2153040
• Length: 530
• Species: Mus musculus
• Alignment Length: 571
• Identity: 176/571 - (30%)
• Similarity: 279/571 - (48%)
• Gaps: 100/571 - (17%)

  Fly    54 RLSAIAMAI---EFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLR 115
            ||...:||:   ||.||.|.::|:|:||.:|:.....||.|.|||::||.:.|::||.||.|:.|
Mouse    34 RLVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRAR 98

  Fly   116 WGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGSVAALVSGEATTG 180
            ||||||.|..|:..::.|:.|        .|.|||                 .|:|||:.
Mouse    99 WGRRRPYILTLAIMMLLGMAL--------YLNGDA-----------------VVSALVAN----- 133

  Fly   181 PSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAI 245
             ......:|:.:|::|:||.||.||....|.:.||.|:|..:::.|.:...|||.||||.:||.:
Mouse   134 -PRQKLIWAISITMVGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYIL 197

  Fly   246 GGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLITVTTFREIPLPLIEQDELLRPLSEQAIKKE 310
            |.:||....:|..:|.....:|....::..:|::..:.:..|.||    :|....|.|:|
Mouse   198 GAIDWVHLDLGRLLGTEFQVMFFFSALVLILCFITHLCSIPEAPL----RDAATDPPSQQ----- 253

  Fly   311 LKKKNNTIYYIQETTQLELQMASDDPK--RLEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPV 373
                                    ||:  .|.| .|.::.|....|:..|        :|.:.||
Mouse   254 ------------------------DPQGSSLSA-SGMHEYGSIEKVKNGG--------ADTEQPV 285

  Fly   374 ----------------SLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGD 422
                            |:|:.|:::..||...|.|.:::|..|...::..|:||||:|:.|:|||
Mouse   286 QEWKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCVSHLIGWTAFLSNMLFFTDFMGQIVYHGD 350

  Fly   423 PTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWFGTKAVYISGMIYYGIGMLVL 487
            |..|.||...|.||.||..||||:.|.:...|:||.....::.:.|.|.:|..|.:.:|:|...:
Mouse   351 PYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKAMVSYIGLKGLYFMGYLLFGLGTGFI 415

  Fly   488 GLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQARGLGTDVAI 549
            ||:|..:..||..:..|::..|::||||.|:|.||.:.  ..:.|:..   |..|.||.|.|.|.
Mouse   416 GLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYHREE--EKEKGQEAPGGPDNQGRGKGVDCAA 478

  Fly   550 ISSMVFIAQLIVSLSVGPLVSWMDTTCAVLYASTFLSFL-AAIAAMFVLYV 599
            ::.||.:||::|...:|.||:...:...|:..::.:|.: ....|:||.||
Mouse   479 LTCMVQLAQILVGGGLGFLVNMAGSVVVVVITASAVSLIGCCFVALFVRYV 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	167/537 (31%)
		MFS	444..>597	CDD:119392	47/156 (30%)
Slc45a2	NP_444307.1	MFS_2	36..524	CDD:290085	169/562 (30%)
		MFS	<39..231	CDD:119392	76/222 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..299		4/31 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7345
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	1	1.000	-	-		otm42424
orthoMCL	1	0.900	-	-		OOG6_100660
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5076
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.840