DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc45-1 and Slc45a4

DIOPT Version :9

Sequence 1:	NP_001261618.1	Gene:	Slc45-1 / 39055	FlyBaseID:	FBgn0035968	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001028391.2	Gene:	Slc45a4 / 106068	MGIID:	2146236	Length:	785	Species:	Mus musculus

Alignment Length:	751	Identity:	188/751 - (25%)
Similarity:	301/751 - (40%)	Gaps:	223/751 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KTRENHAREQDRDYSH--VFRRKTRFEMFRLSAIAMAIEFAYAAETSFVSPILLQIGVDHKHMSM 89
            |.|:..|..|:...|.  :.|..||..:.. .|:....||.||.||:.|:|||||||:..|:.|:
Mouse    27 KPRDPEAETQEETTSEGSIDRIPTRLWVMH-GAVMFGREFCYAMETALVTPILLQIGLPEKYYSL 90

  Fly    90 TWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILSFGIMCGLILVPYGKDLGLLLGDAGYTY 154
            ||.|||::|...:||:||.||||.|.||||||.|..|..|::.|:.|...|..:||.|||.
Mouse    91 TWFLSPVLGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLIGVALFLNGSAIGLALGDV---- 151

  Fly   155 AESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVILTILGMVLLDFDADTCQTPARTYLLDMC 219
                                      ||..  ...::||:||:|:|||.||..:.|.|.||||:.
Mouse   152 --------------------------PSRQ--PIGIVLTVLGVVVLDFSADATEGPIRAYLLDVV 188

  Fly   220 VPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGSFMGGNIPTVFTLVTIIFAVCYLI---- 280
            ..|||..|:.:.|..||.||.|||.:||:||..|.:|.:.......:|....:||:|...:
Mouse   189 DSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGDWFQTQNQVLFFFAAVIFSVSVALHLFS 253

  Fly   281 ---------------------------------------------------TVTTFREIPLPLIE 294
                                                               .|.:..|:.|..::
Mouse   254 IEEEQYSPQQDRGPEDPTLPGTSVQPGAPAPASRLSSLGGGMQDGSPPFPDEVQSEHELSLDYLD 318

  Fly   295 QD---------------------ELL--------------RPLSEQAIKKEL--KKKNNTIYYIQ 322
            .|                     :||              .|.:.|:..:||  .|......:::
Mouse   319 VDIVRSKSDSVLHMADATLDMEPQLLFLHDIEPSIFQDASYPSTPQSTSQELLRAKLPRLSTFLR 383

  Fly   323 ETTQ---------------------------------LELQMASDDPKR---------------- 338
            |:|:                                 |:..:.|...:|
Mouse   384 ESTKEDDTLLDNHLNEAKVPNGRGSPPINSLSRSKVDLKPSVTSGSMRRRRHMFHRQASSTFSYY 448

  Fly   339 ------------------------------LEALQGSYQNGYSPAVEKQGKSQDLETQSDYDAPV 373
                                          |:..|.|.....|.|....|.::..|.:::    .
Mouse   449 GKIGSHCYRYRRANAVVLIKPSRSMSDLYDLQQRQRSRHRNQSGATASSGDTESEEGETE----T 509

  Fly   374 SLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFVGEAVFHGDPTAAPNSEAALNYEAG 438
            :::....|:..||..:..|.|.:|..|...:...:::|||:|:.:|.|:|.|..||.....|.||
Mouse   510 TVRLLWLSMLKMPKELMWLCLCHLLTWFSVIAEAVFYTDFMGQVIFKGNPQAPSNSTKWHAYNAG 574

  Fly   439 VRFGCWGMAIYAFSCSIYSLSVTKLMKWF--GTKAVYISGMIYYGIGMLVLGLWPTKWGVLVFST 501
            |:.||||:.|||.:.:|.|..:.|.:..:  ..:.:|:.|.:.:.:|..|:.::|..:..:|..:
Mouse   575 VKMGCWGLVIYAATGAICSALLQKYLDNYDLSIRIIYMLGTLGFSVGTAVMAMFPNVYVAMVTIS 639

  Fly   502 SAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQARGLGTDVAIISSMVFIAQLIVSL 563
            :.|::..:|...|:.|:..||     .||  |.|   |....||.|.|.||:|..|:|:|::|:.
Mouse   640 TMGVVSMSISYCPYALLGHYH-----DIK--EYVHHSPGNSKRGFGIDCAILSCQVYISQILVAS 697

  Fly   564 SVGPLVSWMDTTCAVLYASTFLSFLAAIAAMF-VLY 598
            ::|.:|..:::...:...::..|||..:.|.| |:|
Mouse   698 ALGGVVDAVNSIVVIPIVASVGSFLGFLTATFLVIY 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_001261618.1	GPH_sucrose	49..568	CDD:273545	173/694 (25%)
Slc45-1	NP_001261618.1	MFS	444..>597	CDD:119392	43/158 (27%)
Slc45a4	NP_001028391.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		5/15 (33%)
		MFS	53..>275	CDD:391944	89/254 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..309		1/49 (2%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..430		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..505		6/26 (23%)
		MFS	<514..726	CDD:391944	64/218 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..772
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849636
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69908
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46818
OrthoDB	1	1.010	-	-		D1230185at2759
OrthoFinder	1	1.000	-	-		FOG0000889
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19432
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5076
SonicParanoid	1	1.000	-	-		X285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890