Protein Alignment Slc45-1 and slc45a4

DIOPT Version :10

• Sequence 1: NP_648292.1
• Gene: Slc45-1 / 39055
• FlyBaseID: FBgn0035968
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: XP_004915080.1
• Gene: slc45a4 / 100493215
• XenbaseID: XB-GENE-6043814
• Length: 784
• Species: Xenopus tropicalis
• Alignment Length: 777
• Identity: 204/777 - (26%)
• Similarity: 322/777 - (41%)
• Gaps: 226/777 - (29%)

  Fly     1 MVGVTADASQANQLSSVRNPMIKYMLK---TRENHAREQDRDYSHVFRRKTRFEMFRLSAIAMAI 62
            |....|| |::.|:..:  |:.|  ||   |:||.:|::....|.:.|...|..:.. .|:....
 Frog     3 MAPQNAD-SESMQVQEL--PLTK--LKKEETKENESRDETISESSIDRIPVRLWVMH-GAVMFGR 61

  Fly    63 EFAYAAETSFVSPILLQIGVDHKHMSMTWGLSPLIGFFMSPLLGSISDRCKLRWGRRRPIISILS 127
            ||.||.||:.|:|:|||||:..::.|:||.|||::|...:||:||.||||.||||||||.|..|.
 Frog    62 EFCYAMETALVTPVLLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLRWGRRRPFILALC 126

  Fly   128 FGIMCGLILVPYGKDLGLLLGDAGYTYAESALNFTSSSGGSVAALVSGEATTGPSASDYKFAVIL 192
            .|::.|:.|...|..:||.:||.                              |...  ...::|
 Frog   127 VGVLLGVALFLNGSVIGLSIGDV------------------------------PDRQ--PIGIVL 159

  Fly   193 TILGMVLLDFDADTCQTPARTYLLDMCVPEEQPKAMTMFALFAGFGGTIGYAIGGVDWETTHIGS 257
            |:||:|:|||.||..:.|.|.||||:...|||..|:.:.|..||.||.|||.:||:||..|.:||
 Frog   160 TVLGVVVLDFCADATEGPIRAYLLDVADNEEQDMALNIHAFSAGLGGAIGYMLGGLDWTQTFLGS 224

  Fly   258 FMGGNIPTVFTLVTIIFAVCYLITVTTFRE--------------IPLPLIEQDELLRPLSEQAIK 308
            ........:|....|||:|..::.:.:..|              ..|..::....:.|:|...:.
 Frog   225 LFKSQEQVLFFFAAIIFSVSVVLHLFSIEEEQYSPQQDRLEDEGDTLSSVKMSSTIAPMSRLNVI 289

  Fly   309 KE--------------------------LKKKNNTIYYIQETT---QLELQMASD-DP------- 336
            .|                          ::.|::::.::.:.|   :.||...|| :|
 Frog   290 NEDEAYSTFPDEVQSEHDLSLDFLEVDIVRSKSDSVLHVPDATLDYESELLFLSDIEPSIFQDCS 354

  Fly   337 -----------------KRLEAL------------------------------------------ 342
                             .||.|.
 Frog   355 YPNTPRSNSQELMKSKFNRLSAFLRENEKEEEMLLDNHINEAKVPNGSDYLPKDNLNGHTAIGMK 419

  Fly   343 -----------------QGSYQNGYSPAV-----------------------------EKQGKSQ 361
                             |.||...|...|                             :||.:.|
 Frog   420 QSCTANSMRRRRHMFYRQPSYTFSYYGKVGSHRYRFRRANAILLIKSSRSMNDIYDIQKKQRQRQ 484

  Fly   362 DLETQS------------DYDAPVSLKAYLKSIFIMPYSMRMLALTNLFCWMGHVTYCLYFTDFV 414
            ....||            :.:...:::....|:..||..:..|.:.:|..|...:...:::|||:
 Frog   485 RHRNQSGATNSSGDTESEEGETETTVRLLWLSMLKMPKELMRLCVCHLLTWFSIIAEAVFYTDFM 549

  Fly   415 GEAVFHGDPTAAPNSEAALNYEAGVRFGCWGMAIYAFSCSIYSLSVTKLMKWF--GTKAVYISGM 477
            |:.:|.|||.|..||....||.|||:.||||:.|||.:.::.|..:.|.:..:  ..|.:||.|.
 Frog   550 GQVIFEGDPQALFNSTELHNYNAGVQMGCWGLVIYAATAAVCSALLQKYLDNYDLSIKVIYILGT 614

  Fly   478 IYYGIGMLVLGLWPTKWGVLVFSTSAGILYGTIFTVPFILVARYHAKNCFSIKNGEIV---PLKQ 539
            :.:.||..|:.::|..:..::..::.||:..:|...|:.|:.:||     .||  |.:   |...
 Frog   615 LGFSIGTAVMSIFPNVYVSMIMISTMGIVSMSISYCPYALLGQYH-----EIK--EYIHHSPGNS 672

  Fly   540 ARGLGTDVAIISSMVFIAQLIVSLSVGPLVSWMDTTCAV-LYAS--TFLSFLAAIAAMFVLY 598
            .||.|.|.||:|..|:|:|::|:.::|.:|..:.|...: |.||  :||.||.  ||..|:|
 Frog   673 KRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPLVASVGSFLGFLT--AAFLVIY 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc45-1	NP_648292.1	MFS_SLC45_SUC	52..591	CDD:340871	184/714 (26%)
slc45a4	XP_004915080.1	MFS	51..>282	CDD:475125	90/263 (34%)
		MFS	<513..725	CDD:475125	70/218 (32%)