Protein Alignment Rdl and glrb

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001072255.1
• Gene: glrb / 779708
• XenbaseID: XB-GENE-1011734
• Length: 497
• Species: Xenopus tropicalis
• Alignment Length: 563
• Identity: 182/563 - (32%)
• Similarity: 263/563 - (46%)
• Gaps: 152/563 - (26%)

  Fly    60 SAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKR 124
            |.||:...||||.|||||:.|.||:|.|.:::.|..|:.|..||:.::.:.||.|.||||   |.
 Frog    57 SNILNRLLVSYDPRVRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQRWNDPRL---KL 118

  Fly   125 P----GVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
            |    |.:.|:|.....|.:|.||.||.|||.:.||..|..|..:.:...|.:..|:||:||.||
 Frog   119 PNDFRGSDALTVDPTMFKCLWKPDLFFANEKNANFHDVTQENILLFIFRDGDVLLSMRLSITLSC 183

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEI--- 247
            |::|..||||.|.|.:::||||||..|:|:.|:.| ..|.| .::.||||.:     :..:|
 Frog   184 PLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSG-DPVQM-EKIALPQFDI-----KTEDIEYG 241

  Fly   248 NLT-----TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTV 307
            |.|     ||.|:.:.......|.:|:|::.:|.|:.|||::||:|||:|.:|:.|||.||:.:|
 Frog   242 NCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSV 306

  Fly   308 LTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYM---AKRIQMRKQRFMAIQ 369
            |::.:..::....|||:||||:|||:|..|.:..||||:|||.|..:   .|||:..|      .
 Frog   307 LSLASECTTLAQELPKVSYVKAIDVWLIACLLFGFASLVEYAVVQVLLNSPKRIEAEK------A 365

  Fly   370 KIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHH 434
            |||:.::.:..|||..:.|     .|.|.|
 Frog   366 KIAKAEQAEGKGANAAKKN-----TVNGTG----------------------------------- 390

  Fly   435 AHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGC---------------SIVGPLFQEVRFKVHDP 484
                            .||..|.:|  ||...|               ||||.|.::.....:|
 Frog   391 ----------------TPIHISTLQ--VGENRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYD- 436

  Fly   485 KAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPG 549
               ..|..:|  ||.|.|..|:.                  ....||          ||..:.|.
 Frog   437 ---CYGKPIE--VNNGLGKSQAK------------------NNKKPP----------PAKPVIPS 468

  Fly   550 KVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYL 592
            :.|:              ||.|||.:||.||:.||::||::||
 Frog   469 EAKR--------------IDLYSRALFPFCFLFFNVIYWLVYL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	71/194 (37%)
		Cys-loop	185..199	CDD:349809	8/13 (62%)
		Neur_chan_memb	274..588	CDD:460753	90/331 (27%)
glrb	NP_001072255.1	LIC	38..496	CDD:455710	180/560 (32%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	72/195 (37%)
		Cys-loop	183..197	CDD:349811	8/13 (62%)