DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and gabra1

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_009293960.1	Gene:	gabra1 / 768183	ZFINID:	ZDB-GENE-061013-194	Length:	470	Species:	Danio rerio

Alignment Length:	546	Identity:	158/546 - (28%)
Similarity:	230/546 - (42%)	Gaps:	158/546 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            ||||....||.|:||..|....||...::|.||..:|:..|::|:|.:|||.|.|.||.: |.|
Zfish    56 ILDSLLDGYDNRLRPGLGERVTEVKTDIFVTSIGPVSDHDMEYTIDVFFRQSWKDERLKF-KGP- 118

  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191
            :..|.:.:.....||.|||||.|.|:|..|..|..|:.:|:...|::..::|||:.|.|||:|:.
Zfish   119 MAVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEEGTLLYTMRLTVRAECPMHLED 183

  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFW-RDGLSSVGMSSE-VELPQFRVLGHRQRATEINLTTGNY 254
            ||||...|.::..|:.||..::.|.| |....||.::.: ..|.|:.::|....:..:..:||.|
Zfish   184 FPMDAHACPLKFGSYAYTRAEVVYVWTRGAAQSVVVADDGSRLNQYDLMGQSVDSGVVQSSTGEY 248

  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319
            ..:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...
Zfish   249 VVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 313

  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKR--------IQMRKQRFMAIQKIAEQKK 376
            :|||::|..::|.::..|:..||::|:|:|||.|..||        :...||:         :||
Zfish   314 SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKQK---------KKK 369

  Fly   377 QQLDGANQQQANPNPNA---NVG-GPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHS 437
            :.|...|.........|   |:. .||...:....|                |.
Zfish   370 ESLLKKNNTYTAATATAFAPNIARDPGLATIAKSAP----------------PP----------- 407

  Fly   438 HGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRG 502
               |..||:                                    :||
Zfish   408 ---PTEPKE------------------------------------EPK----------------- 416

  Fly   503 GPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSD 567
                  |.|                         |||.              |..|.:     |.
Zfish   417 ------PKP-------------------------PEAK--------------KTFNSV-----SK 431

  Fly   568 IDKYSRIVFPVCFVCFNLMYWIIYLH 593
            ||:.:||.||:.|..|||:||..||:
Zfish   432 IDRIARIAFPLLFGTFNLVYWATYLN 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	61/184 (33%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	78/325 (24%)
gabra1	XP_009293960.1	LIC	17..455	CDD:273305	156/542 (29%)
		Neur_chan_LBD	54..261	CDD:280998	72/206 (35%)
		Neur_chan_memb	268..452	CDD:280999	78/325 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010