DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and gabrz

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001108214.2	Gene:	gabrz / 561738	ZFINID:	ZDB-GENE-080303-26	Length:	447	Species:	Danio rerio

Alignment Length:	562	Identity:	157/562 - (27%)
Similarity:	258/562 - (45%)	Gaps:	158/562 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ISAILDSFSVS----------------YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLD 107
            ||.|:|. ||:                |:|.:||.:|..||.||:::.:.||.::||:.||:|..
Zfish    16 ISRIMDG-SVANTEEILPPTIQKLMKGYNKYLRPFFGNGPVTVGMSLDIASIDTISEINMDYTAT 79

  Fly   108 FYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGS 172
            .:.||.|||.||.:   .|.::||:....::.:||||||.|:.|:|:.|..|..|..||:..:|:
Zfish    80 IFLRQRWTDERLCF---DGNKSLSLDGRLVELLWVPDTFIVDSKKSFLHDITVENRLIRIFPNGT 141

  Fly   173 ITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRV 237
            :..::|:|.|.:|.|:|..:|||||.|.:::||:||.::|:.::|..|..||.....::|.|:.:
Zfish   142 VLYALRITTTVACSMDLTKYPMDRQTCMLQLESWGYNVKDVVFYWTRGNQSVSGLDHLQLAQYTL 206

  Fly   238 LGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVAL 302
            ..|....:|....||||.:|....:..||:.|::::.|:||..:|::||||||:::::.|||:.:
Zfish   207 EDHYTSESEAVYETGNYPKLIFHFKLKRSILYFILETYVPSSALVVLSWVSFWISQSSVPARICI 271

  Fly   303 GVTTVLTMTTLMSSTNAALPKIS-YVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFM 366
            ||||||||||||.....:||..: ::|:||||||.||..:|.:|:|||..            .|.
Zfish   272 GVTTVLTMTTLMMGARTSLPNANCFIKAIDVYLGICFSFIFGALIEYAVA------------HFC 324

  Fly   367 AIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGH 431
            .:.:                    |||
Zfish   325 TLHQ--------------------PNA-------------------------------------- 331

  Fly   432 GHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENT 496
             .:|:.:|      |.:..|....:.|..:.|:..          :|.:..: :..|:.|::.|.
Zfish   332 -ANAYMYG------QEMQEREDEMNGIVTSFGSHA----------LRARKRE-EMLSRMGSVNNP 378

  Fly   497 VNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLL 561
            .                                |.|...|..::.|       :.:..|.:::..
Zfish   379 T--------------------------------PSESKEDVSSSQP-------QTRCTKCMSRAR 404

  Fly   562 GI----------TPSDIDKYSRIVFPVCFVCFNLMYWIIYLH 593
            .|          .|..||.|||:.||:.||..||:||..||:
Zfish   405 RIIRCLYCCKVENPHYIDNYSRLTFPLSFVIINLLYWTYYLY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	65/182 (36%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	73/324 (23%)
gabrz	NP_001108214.2	LIC	26..444	CDD:273305	149/547 (27%)
gabrz	NP_001108214.2	LGIC_ECD_GABAAR_pi	54..235	CDD:349805	66/183 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820