DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and glrbb

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_021336678.1	Gene:	glrbb / 445193	ZFINID:	ZDB-GENE-040801-106	Length:	502	Species:	Danio rerio

Alignment Length:	539	Identity:	161/539 - (29%)
Similarity:	255/539 - (47%)	Gaps:	107/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKR 124
            |.||:...::||.|:|||:.|.|||..|.:::.|..|:.|..||:.::.:.||.|.||||...:.
Zfish    65 SNILNKLLITYDPRIRPNFKGIPVEDRVNIFINSFGSIQETTMDYRVNIFLRQRWNDPRLRLPQD 129

  Fly   125 PGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNL 189
            ...::|:|..:..|.:|.||.||.|||.:.||..|..|..:.:..:|.:..|:||::|.|||::|
Zfish   130 FKSDSLTVDPKMFKCLWKPDLFFANEKSANFHDVTQENILLFIFRNGDVLISMRLSVTLSCPLDL 194

  Fly   190 QYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEI-NLT--- 250
            ..||||.|.|.:::||||||..|:::.|:.| ..|.| .|:.||||.:   :|...|. |.|
Zfish   195 TLFPMDTQRCKMQLESFGYTTDDLQFMWQSG-DPVQM-DEIALPQFDI---KQEDIEYGNCTKYY 254

  Fly   251 --TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTL 313
              ||.|:.:.......|.:|:|::.:|.|:.|||::||:|||:|.:|:.|||.||:.:||::::.
Zfish   255 AGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGILSVLSLSSE 319

  Fly   314 MSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQ 378
            .:|..:.|||:||||:||::|..|.:..||||:|||.|     ::.:...:.:..::.....|::
Zfish   320 CTSLASELPKVSYVKAIDIWLIACLLFGFASLVEYAVV-----QVMLNSPKLLEAERAKIATKEK 379

  Fly   379 LDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHA 443
            .:|       ..|..|.                   :|   |||..|.|              .:
Zfish   380 AEG-------KTPAKNT-------------------IN---GMGSTPIH--------------VS 401

  Fly   444 PKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHG 508
            ..|....|.......:.::.|...||||.|.::......|    ..|..:|      .|...|..
Zfish   402 TLQVTETRCKKVCTSKSDLRTNDFSIVGSLPRDFELSNFD----CYGKPIE------VGSAFSKS 456

  Fly   509 PGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSR 573
            ........||                  |:..:|:                    ....||.|:|
Zfish   457 QAKNNKKPPP------------------PKPVIPS--------------------AAKRIDLYAR 483

  Fly   574 IVFPVCFVCFNLMYWIIYL 592
            .:||..|:.||::||.:||
Zfish   484 ALFPFSFLFFNVIYWSVYL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	68/188 (36%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	75/313 (24%)
glrbb	XP_021336678.1	Neur_chan_LBD	53..501	CDD:332142	159/536 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810