DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rdl and nAChRalpha2

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_524482.1	Gene:	nAChRalpha2 / 42919	FlyBaseID:	FBgn0000039	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	105/489 - (21%)
Similarity:	185/489 - (37%)	Gaps:	126/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PLPRTPLLTIW-------LAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYD 71
            |.|...|..||       |.:.:.|:.:        ||||         :.:...:.|....:|:
  Fly    10 PRPIALLAHIWRHCKPLCLLLVLLLLCE--------TVQA---------NPDAKRLYDDLLSNYN 57

  Fly    72 KRVRP---NYGGPPVEVGVTMYVLSISSLSEVKMD---FTLDFYFRQFWTDPRLAY--RKRPGVE 128
            :.:||   |.....|::|     |.:|.|.::.:.   .|.:.:....|.|.:..:  .:..||.
  Fly    58 RLIRPVSNNTDTVLVKLG-----LRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVT 117

  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193
            .|.|.||   :||:||....|.....: :.||..:.| :|::|.:..:......:||.::::|||
  Fly   118 ELYVPSE---HIWLPDIVLYNNADGEY-VVTTMTKAI-LHYTGKVVWTPPAIFKSSCEIDVRYFP 177

  Fly   194 MDRQLCHIEIESFGY--TMRDIRYFW----RDGLSSVGMSSEVELP--QFRVLGHRQRATE--IN 248
            .|:|.|.::..|:.|  ...|:::..    :|....:|:......|  ::.:||......|  ..
  Fly   178 FDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKYYP 242

  Fly   249 LTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPA----RVALGVTTVLT 309
            .....|..:...|...|...:|.:.:.||...|..:|.:.|:|     ||    ::||.::.:|:
  Fly   243 CCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYL-----PADSGEKIALCISILLS 302

  Fly   310 MT-------TLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATV---------------- 351
            .|       .::.||:.|||.:.      .||  .|.|:...|....|:
  Fly   303 QTMFFLLISEIIPSTSLALPLLG------KYL--LFTMLLVGLSVVITIIILNIHYRKPSTHKMR 359

  Fly   352 ----GYMAKRIQ----MRKQ----RFMAIQKI------AEQKKQQ--LDGANQQQANPNPNANVG 396
                .:..||:.    ||..    |.:|..||      ::.|..|  :|.........:|::...
  Fly   360 PWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKFGQALMDEMQMNSGGSSPDSLRR 424

  Fly   397 GPGGVGVG--------------PGGPGGPGGGVN 416
            ..|.||.|              .|..|..|||::
  Fly   425 MQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	43/197 (22%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	44/204 (22%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	49/228 (21%)
nAChRalpha2	NP_524482.1	LIC	47..544	CDD:273305	94/435 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100