DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rdl and gabra6a

DIOPT Version :9

Sequence 1:NP_001261617.1 Gene:Rdl / 39054 FlyBaseID:FBgn0004244 Length:608 Species:Drosophila melanogaster
Sequence 2:XP_005173169.1 Gene:gabra6a / 393704 ZFINID:ZDB-GENE-040426-1692 Length:435 Species:Danio rerio


Alignment Length:547 Identity:163/547 - (29%)
Similarity:238/547 - (43%) Gaps:145/547 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 GGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFW 114
            |...:...||:.|||.....||.|:||..|....||...::|.|...:|:|.|:||:|.:|||.|
Zfish    18 GKQKINSENITRILDGLLEGYDNRLRPGSGVSVTEVKTDIFVTSFGPVSDVNMEFTMDMFFRQMW 82

  Fly   115 TDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRL 179
            .|.|||:  :..:|.|.:.:..:..||.|||||.|.::|..|..|:.|:..|:..:|::..::||
Zfish    83 VDERLAF--QGPIEILPLNNRMVDKIWTPDTFFRNARKSLAHNMTSPNKLFRIMQNGTVFYTMRL 145

  Fly   180 TITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGL-SSVGMSSE-VELPQFRVLGHRQ 242
            |::|.|||.|:.||||...|.:...|:.||.|:|.|.||.|| :||....| ..|.|:.:||...
Zfish   146 TVSAVCPMVLRDFPMDGHTCPLYFGSYAYTNREIVYTWRKGLEASVDFPPESSSLLQYDLLGQTL 210

  Fly   243 RATEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTV 307
            .......:||.||.........|.:||:|||.|||..::|::|.||||:|:.:.|||...|:|||
Zfish   211 FTETYKFSTGLYSVQVVHFYLQRKLGYHLIQTYIPLIMVVVLSQVSFWINKESVPARTVAGITTV 275

  Fly   308 LTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIA 372
            ||||||..|..::|||:||..::|.::..||..|.::|:|:|.|.|.|.....|:...:....|.
Zfish   276 LTMTTLSISARSSLPKVSYATAMDWFIAVCFAFVASALVEFAAVNYYATLEANRENHKLPRGSIV 340

  Fly   373 EQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHS 437
            |.:.|   |::.:..:|..:.:                                     .:....
Zfish   341 ESQAQ---GSDDEPESPQSDTS-------------------------------------AYSRKR 365

  Fly   438 HGHP--HAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGG 500
            .|:|  .||:..|                       |:|.:                        
Zfish   366 RGYPVSEAPRTRV-----------------------PIFLQ------------------------ 383

  Fly   501 RGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITP 565
                                     |...||                          |.:|..| 
Zfish   384 -------------------------GSAFPP--------------------------NMMLAGT- 396

  Fly   566 SDIDKYSRIVFPVCFVCFNLMYWIIYL 592
            |.|||||||:||:.|..|||:||.|||
Zfish   397 SAIDKYSRILFPLAFGIFNLVYWYIYL 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RdlNP_001261617.1 LGIC_ECD_GABAR_RDL-like 83..266 CDD:349809 68/184 (37%)
Neur_chan_memb 274..588 CDD:397193 72/315 (23%)
gabra6aXP_005173169.1 LIC 2..422 CDD:273305 160/544 (29%)
Neur_chan_LBD 28..234 CDD:280998 77/207 (37%)
Neur_chan_memb 242..419 CDD:280999 72/315 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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