DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rdl and lgc-38

DIOPT Version :9

Sequence 1:	NP_001261617.1	Gene:	Rdl / 39054	FlyBaseID:	FBgn0004244	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001355511.1	Gene:	lgc-38 / 3565717	WormBaseID:	WBGene00017389	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	608	Identity:	224/608 - (36%)
Similarity:	304/608 - (50%)	Gaps:	171/608 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KMDKLARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAAT----GGGSMLG-DVNISAILD 64
            |.|||...||                              ||:|    ||.|... :.|::.:||
Worm    23 KSDKLIEYAP------------------------------QASTEPTLGGESNENLENNVTRLLD 57

  Fly    65 SFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVE- 128
            ....|:|:|:||||||||:||.:|.:|.:||::|||.||:|||.|.||.|.|||||:..  .||
Worm    58 KLIASHDRRIRPNYGGPPIEVNITAHVTTISAVSEVSMDYTLDLYLRQIWKDPRLAWES--DVED 120

  Fly   129 TLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFP 193
            :|::|.:.:|.||.|||||.|||:|:||.||:.|.|:|:.:.|::.||||||:||:|||:|..||
Worm   121 SLTIGIDMVKTIWTPDTFFPNEKKSFFHEATSHNSFLRIDNHGNVLRSIRLTVTANCPMSLHTFP 185

  Fly   194 MDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLA 258
            :|||.|.:|:||:||:.:||.|.|. |.::|.:...|.|..|.:..|:.....|:|:|||||||.
Worm   186 LDRQECALEVESYGYSTKDIIYHWH-GTNAVTIDENVHLAHFTIGEHKHIERTISLSTGNYSRLT 249

  Fly   259 CEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPK 323
            ....|.|::|:||||||.||.|||:||||||||||.|..||||:||||||||||||:||||:|||
Worm   250 AYFLFKRNIGFYLIQIYFPSSLIVVISWVSFWLNREAVQARVAIGVTTVLTMTTLMTSTNASLPK 314

  Fly   324 ISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKR---------IQ-MRKQRFMAIQ---KIAEQK 375
            :|||||:||:||.||.:|||||||||.:||:.||         :| ...:.|..||   |.....
Worm   315 VSYVKSLDVFLGVCFFIVFASLLEYAAIGYLMKRNRSVPAASPVQYYETEEFFEIQCHPKFVRGA 379

  Fly   376 KQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGH 440
            ....||..:::|:...:.|...                        .....:.:.:.||..|.||
Worm   380 INYCDGVLKREASRKKSRNRRD------------------------SSMKNYQNNNIHHRPSDGH 420

  Fly   441 PHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQ 505
                             :.|.:         ||...|
Worm   421 -----------------VDQRI---------PLLSMV---------------------------- 431

  Fly   506 SHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDK 570
               |.|.....|..|..|                             ||:         |:.:|.
Worm   432 ---PMPPIPFKPQNGAWG-----------------------------KVR---------PAQVDL 455

  Fly   571 YSRIVFPVCFVCFNLMYWIIYLH 593
            :||..||:.||.|:::||..|::
Worm   456 FSRFAFPIFFVIFHIVYWTYYIN 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	90/183 (49%)
Rdl	NP_001261617.1	Neur_chan_memb	274..588	CDD:397193	99/326 (30%)
lgc-38	NP_001355511.1	LIC	42..476	CDD:273305	213/555 (38%)
		LGIC_ECD_GABAR_RDL-like	76..257	CDD:349809	90/183 (49%)
		Cys-loop	177..191	CDD:349809	9/13 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I1474
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69070
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1039
Isobase	1	0.950	-	0	Normalized mean entropy	S4221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D226476at33208
OrthoFinder	1	1.000	-	-		FOG0016987
OrthoInspector	1	1.000	-	-		oto20115
orthoMCL	1	0.900	-	-		OOG6_101786
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780