DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rdl and GLRA1

DIOPT Version :9

Sequence 1:NP_001261617.1 Gene:Rdl / 39054 FlyBaseID:FBgn0004244 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_001139512.1 Gene:GLRA1 / 2741 HGNCID:4326 Length:457 Species:Homo sapiens


Alignment Length:595 Identity:185/595 - (31%)
Similarity:272/595 - (45%) Gaps:172/595 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSDSKMDKLARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDS 65
            ::.||..:.||.||.|.:|                                        |..||.
Human    20 LAASKEAEAARSAPKPMSP----------------------------------------SDFLDK 44

  Fly    66 F---SVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGV 127
            .   :..||.|:|||:.||||.|...:::.|..|::|..||:.::.:.||.|.||||||.:.|. 
Human    45 LMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPD- 108

  Fly   128 ETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYF 192
            ::|.:....:.:||.||.||.|||.::||..||.|:.:|:..:|::..|||:|:|.:|||:|:.|
Human   109 DSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNF 173

  Fly   193 PMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQ-RATEINLTTGNYSR 256
            |||.|.|.:::|||||||.|:.:.|:: ..:|.::..:.||||.:...:. |....:..||.::.
Human   174 PMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTC 237

  Fly   257 LACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAAL 321
            :.......|.|||||||:||||.||||:||:|||:|.:|.||||.||:||||||||..|.:.|:|
Human   238 IEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASL 302

  Fly   322 PKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQ 386
            ||:||||:||:::..|.:.||::|||||.|.:                 ::.|.|:.|....:::
Human   303 PKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF-----------------VSRQHKELLRFRRKRR 350

  Fly   387 ANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNR 451
            .:.:|..|:......|         .|..|.. ..||||                          
Human   351 HHKSPMLNLFQEDEAG---------EGRFNFS-AYGMGP-------------------------- 379

  Fly   452 PIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGG 516
                :.:|   ...|.|:                   ||....||.|                  
Human   380 ----ACLQ---AKDGISV-------------------KGANNSNTTN------------------ 400

  Fly   517 PPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFV 581
                         ||                |...|..:::.||.......|||.|||.||:.|:
Human   401 -------------PP----------------PAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFL 436

  Fly   582 CFNLMYWIIY 591
            .||:.|||||
Human   437 IFNMFYWIIY 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RdlNP_001261617.1 LGIC_ECD_GABAR_RDL-like 83..266 CDD:349809 66/183 (36%)
Neur_chan_memb 274..588 CDD:397193 86/313 (27%)
GLRA1NP_001139512.1 LIC 7..446 CDD:273305 183/593 (31%)
Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430 230..235 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..410 9/65 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X271
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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