Protein Alignment Rdl and GABRR2

DIOPT Version :10

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 162/529 - (30%)
• Similarity: 247/529 - (46%)
• Gaps: 135/529 - (25%)

  Fly    70 YDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGS 134
            :|..:||.:|||.:.|||.:.|.|:.|:|||.||||:..|.|.:|.|.|||:..... ::::...
Human    64 HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN-KSMTFDG 127

  Fly   135 EFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLC 199
            ..:|.|||||.|||:.|:|:.|..||.|..:||...|.:..|:|:|:||.|.|:..:||:|.|.|
Human   128 RLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTC 192

  Fly   200 HIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLG-HRQRATEINLTTGNYSRLACEIQF 263
            .:|:||:.||..|:..:|::|..|:....::.|.||.:.. |.........:||.|:||......
Human   193 SLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTL 257

  Fly   264 VRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVK 328
            .|.:.::|:|.|.|:.|:|::||||||::|.|.||||:||:||||||||:::..||::|::||||
Human   258 RRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVK 322

  Fly   329 SIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQR-----FMAIQKIAEQKKQQLDGA-NQQQA 387
            ::|:||...||.||.|:||||.|.|:. .:|.||:|     |..:..:...|...|||: ::.:|
Human   323 AVDIYLWVSFVFVFLSVLEYAAVNYLT-TVQERKERKLREKFPCMCGMLHSKTMMLDGSYSESEA 386

  Fly   388 NPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRP 452
            |                                               ...|:|.:...|...|.
Human   387 N-----------------------------------------------SLAGYPRSHILTEEERQ 404

  Fly   453 IGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGP 517
               ..|..::|..|                :..|..|.|.|:.. .|.|....:|.
Human   405 ---DKIVVHLGLSG----------------EANAARKKGLLKGQ-TGFRIFQNTHA--------- 440

  Fly   518 PGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVC 582
                                                              ||||||::||..::.
Human   441 --------------------------------------------------IDKYSRLIFPASYIF 455

  Fly   583 FNLMYWIIY 591
            |||:||.::
Human   456 FNLIYWSVF 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	68/183 (37%)
		Cys-loop	185..199	CDD:349809	6/13 (46%)
		Neur_chan_memb	274..588	CDD:460753	83/319 (26%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	162/527 (31%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	69/185 (37%)
		Cys-loop	178..192	CDD:349806	6/13 (46%)