Protein Alignment Rdl and GABRG3

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_011519732.1
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 473
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 152/567 - (26%)
• Similarity: 238/567 - (41%)
• Gaps: 165/567 - (29%)

  Fly    56 DVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLA 120
            |.:::.||:.....|||::||:.|..|..:.|.:||.||..:|.:.|::.:|.:|.|.|||.||.
Human    44 DTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLR 108

  Fly   121 YRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
            :...  ::.|::.|..:..||:|||.|.|.|.:..|..||.|:.:|:.:.|.|..::||||.|.|
Human   109 FNST--MKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAEC 171

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLT 250
            .:.|..||||...|.:...|:||...::.|.||.............|.||..:|.|.....:..:
Human   172 QLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTS 236

  Fly   251 TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMS 315
            .|:|..:....:..|.|||:.||.|||..|.|::||||||:.::|||||.|||:|||||||||.:
Human   237 AGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLST 301

  Fly   316 STNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGY------------------------MAK 356
            ....:||::|||.::|:::..||:.|||:|:||||:.|                        :.:
Human   302 IARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPE 366

  Fly   357 RIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGM 421
            ||.::....    :||.|....||      ..|.|.|.:
Human   367 RISLQAPSV----RIALQNYSLLD------MRPPPTAMI-------------------------- 395

  Fly   422 GMGPEHGHGHGHHAHSHGHPHAPKQTVSN----RPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVH 482
                                     |::|    :....:.:.:.:..:.|......::|
Human   396 -------------------------TLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEE------ 429

  Fly   483 DPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLH 547
                 .|.|:...    ||                                            :|
Human   430 -----CKSGSWRK----GR--------------------------------------------IH 441

  Fly   548 PGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHV 594
                           |...::|.|||:.||..|:.|||:||:.||::
Human   442 ---------------IDILELDSYSRVFFPTSFLLFNLVYWVGYLYL 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	57/182 (31%)
		Neur_chan_memb	274..588	CDD:397193	75/341 (22%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	67/206 (33%)
		LIC	50..470	CDD:273305	149/556 (27%)
		Neur_chan_memb	260..467	CDD:280999	75/341 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910