Protein Alignment Rdl and GABRG1

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_775807.2
• Gene: GABRG1 / 2565
• HGNCID: 4086
• Length: 465
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 160/541 - (29%)
• Similarity: 237/541 - (43%)
• Gaps: 138/541 - (25%)

  Fly    55 GDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRL 119
            ||  |:.||:|....||.::||:.|..|..:...:||.||..:..:.|::|:|..|.|.|.|.||
Human    62 GD--ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRL 124

  Fly   120 AYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITAS 184
            .:...  ::.|.:.|..:..||:|||||.|.::|..|..||.|..:|:.:.|.:..::||||.|.
Human   125 KFNST--MKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAE 187

  Fly   185 CPMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINL 249
            |.:.|..||||...|.:|..|:||...:|.|.|:.....|.......|.||..:|.| .:|||..
Human   188 CYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLR-NSTEITH 251

  Fly   250 T-TGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTL 313
            | :|:|..:.......|.|||:.||.|||..|.|::||||||:|::|.|||.:||:|||||||||
Human   252 TISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTL 316

  Fly   314 MSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQ 378
            .:....:|||:|||.::|:::..||:.|||:|:||.|:.|           |.:.||   .|...
Human   317 STIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHY-----------FTSNQK---GKTAT 367

  Fly   379 LDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHA 443
            .|...:.:|:..|          |:.||....|...::|      ..|..:|:
Human   368 KDRKLKNKASMTP----------GLHPGSTLIPMNNISV------PQEDDYGY------------ 404

  Fly   444 PKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHG 508
                            |.:..:.|:.....|::.|          .|...|..::
Human   405 ----------------QCLEGKDCASFFCCFEDCR----------TGSWREGRIH---------- 433

  Fly   509 PGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSR 573
                                                                  |..:.||.|||
Human   434 ------------------------------------------------------IRIAKIDSYSR 444

  Fly   574 IVFPVCFVCFNLMYWIIYLHV 594
            |.||..|..|||:||:.||::
Human   445 IFFPTAFALFNLVYWVGYLYL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	61/183 (33%)
		Neur_chan_memb	274..588	CDD:397193	77/313 (25%)
GABRG1	NP_775807.2	LIC	66..462	CDD:273305	155/530 (29%)
		LGIC_ECD_GABAAR_G	88..269	CDD:349801	61/183 (33%)
		Cys-loop	188..202	CDD:349801	6/13 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910