DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rdl and GABRB1

DIOPT Version :9

Sequence 1:NP_001261617.1 Gene:Rdl / 39054 FlyBaseID:FBgn0004244 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_000803.2 Gene:GABRB1 / 2560 HGNCID:4081 Length:474 Species:Homo sapiens


Alignment Length:580 Identity:193/580 - (33%)
Similarity:281/580 - (48%) Gaps:123/580 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAI---LDSFSVSYDKRVRPNYGGP 81
            ||:..:.|.|...|..|....                 |:|.:   :|.....||.|:||::|||
Human    12 LLSFPVMITMVCCAHSTNEPS-----------------NMSYVKETVDRLLKGYDIRLRPDFGGP 59

  Fly    82 PVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTF 146
            ||:||:.:.|.||..:|||.||:||..||:|.|.|.||:|...|  ..|::.:.....:|||||:
Human    60 PVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIP--LNLTLDNRVADQLWVPDTY 122

  Fly   147 FVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMR 211
            |:|:|:|:.|..|..|..||:|..|::...:|:|.||:|.|:|:.:|:|.|.|.:||||:|||..
Human   123 FLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTD 187

  Fly   212 DIRYFWRDGLSSVGMSSEVELPQFRVLGHRQRATEINLTTGNYSRLACEIQFVRSMGYYLIQIYI 276
            ||.::|..|..:|...:::|||||.::.::..:.::..|||.|.||:...:..|::||:::|.|:
Human   188 DIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYM 252

  Fly   277 PSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMV 341
            ||.||.|:||||||:|.:|:.||||||:||||||||:.:.....||||.|||:||:||..|||.|
Human   253 PSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFV 317

  Fly   342 FASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPG 406
            |.:|||||.|.|:          |..       |..|..||::|..:.|....            
Human   318 FLALLEYAFVNYI----------FFG-------KGPQKKGASKQDQSANEKNK------------ 353

  Fly   407 GPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVG 471
                          :.|.......||:                   |..|.::....|.|     
Human   354 --------------LEMNKVQVDAHGN-------------------ILLSTLEIRNETSG----- 380

  Fly   472 PLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGG---GGPPEG 533
               .||...|.||||     |:           .|:.....|...|.......|..   .|.|..
Human   381 ---SEVLTSVSDPKA-----TM-----------YSYDSASIQYRKPLSSREAYGRALDRHGVPSK 426

  Fly   534 GGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLH 593
            |.....|....:    |:..:.|:|        .|||:||:.||:.|..||::||:.|:|
Human   427 GRIRRRASQLKV----KIPDLTDVN--------SIDKWSRMFFPITFSLFNVVYWLYYVH 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RdlNP_001261617.1 LGIC_ECD_GABAR_RDL-like 83..266 CDD:349809 73/182 (40%)
Neur_chan_memb 274..588 CDD:397193 94/316 (30%)
GABRB1NP_000803.2 LIC 9..472 CDD:273305 191/576 (33%)
Agonist binding. /evidence=ECO:0000250 120..122 1/1 (100%)
Agonist binding. /evidence=ECO:0000250 180..182 1/1 (100%)
Allosteric effector binding. /evidence=ECO:0000250 290..311 10/20 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D226476at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101786
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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