Protein Alignment Rdl and GABRA6

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 170/549 - (30%)
• Similarity: 238/549 - (43%)
• Gaps: 152/549 - (27%)

  Fly    58 NISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYR 122
            |:|.|||:....||.|:||.:||...||...:||.|...:|:|:|::|:|.:|||.|||.||.:
Human    31 NVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKF- 94

  Fly   123 KRPG--VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASC 185
               |  .|.||:.:..:..||.|||||.|.|:|..|..||.|:..|:..:|:|..::||||.|.|
Human    95 ---GGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADC 156

  Fly   186 PMNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDG-LSSVGMSSE-VELPQFRVLGHRQRATEIN 248
            ||.|..||||...|.::..|:.|...:|.|.|:.| |.||.:..| ..|.|:.::|....:..|.
Human   157 PMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIK 221

  Fly   249 LTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTL 313
            ..||.|..:.......|.|||::||||.|..:.||:|.||||:|:.:.|||...|:|||||||||
Human   222 SNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTL 286

  Fly   314 MSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGY---MAKRIQMRKQRFMA-----IQK 370
            ..|...:|||:||..::|.::..||..||::|:|:|.|.|   :..:...||.:|.|     |.|
Human   287 SISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISK 351

  Fly   371 IAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHA 435
            ..|..:.::                                                      ..
Human   352 ATEPLEAEI------------------------------------------------------VL 362

  Fly   436 HSHGHPHAPKQTVS-NRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNG 499
            |.....|..|:..| :.||..|:....|.||     .|:.|..
Human   363 HPDSKYHLKKRITSLSLPIVSSSEANKVLTR-----APILQST---------------------- 400

  Fly   500 GRGGPQSHGP-GPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGI 563
                |.:..| .|..||
Human   401 ----PVTPPPLSPAFGG------------------------------------------------ 413

  Fly   564 TPSDIDKYSRIVFPVCFVCFNLMYWIIYL 592
             .|.||:||||:|||.|..|||:||::||
Human   414 -TSKIDQYSRILFPVAFAGFNLVYWVVYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	70/186 (38%)
		Neur_chan_memb	274..588	CDD:397193	78/323 (24%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	168/546 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910