Protein Alignment Rdl and GABRA5

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 163/545 - (29%)
• Similarity: 237/545 - (43%)
• Gaps: 149/545 - (27%)

  Fly    62 ILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPG 126
            |||.....||.|:||..|....:|...:||.|...:|:.:|::|:|.:|||.|.|.||.: |.|
Human    52 ILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRF-KGP- 114

  Fly   127 VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQY 191
            ::.|.:.:.....||.|||||.|.|:|..|..||.|:.:|:...|::..::||||:|.|||.|:.
Human   115 MQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLED 179

  Fly   192 FPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSE--VELPQFRVLGHRQRATEINLTTGNY 254
            ||||...|.::..|:.|...::.|.|.:|.:...:.:|  ..|.|:.::|.......|:.:||.|
Human   180 FPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEY 244

  Fly   255 SRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNA 319
            :.:.......|.:||::||.|:|..:.||:|.|||||||.:.|||...|||||||||||..|...
Human   245 TIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 309

  Fly   320 ALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQ 384
            :|||::|..::|.::..|:..||::|:|:|||.|..||            ..|...|:.|:.|..
Human   310 SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKR------------GWAWDGKKALEAAKI 362

  Fly   385 QQ-----ANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAP 444
            ::     .|.:.||...|                                     ..|| .|:.|
Human   363 KKKREVILNKSTNAFTTG-------------------------------------KMSH-PPNIP 389

  Fly   445 KQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPK-AHSKGGTLENTVNGGRGGPQSHG 508
            |:   ..|.|.||      |...|:          |..:.| :.||
Human   390 KE---QTPAGTSN------TTSVSV----------KPSEEKTSESK------------------- 416

  Fly   509 PGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKVKDINKLLGITPSDIDKYSR 573
                                                          |..|.:     |.|||.||
Human   417 ----------------------------------------------KTYNSI-----SKIDKMSR 430

  Fly   574 IVFPVCFVCFNLMYWIIYLHVSDVV 598
            |||||.|..|||:||..||:...|:
Human   431 IVFPVLFGTFNLVYWATYLNREPVI 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	61/184 (33%)
		Neur_chan_memb	274..588	CDD:397193	83/319 (26%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	67/199 (34%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	86/324 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		13/91 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910