Protein Alignment Rdl and GABRA4

DIOPT Version :9

• Sequence 1: NP_001261617.1
• Gene: Rdl / 39054
• FlyBaseID: FBgn0004244
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 182/568 - (32%)
• Similarity: 260/568 - (45%)
• Gaps: 105/568 - (18%)

  Fly    58 NISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYR 122
            |.:.||||....||.|:||.:|||..||...:||.|...:|:|:|::|:|.:|||.|.|.||.|
Human    47 NFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKY- 110

  Fly   123 KRPG-VETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCP 186
              .| :|.|.:.:..:..:|.|||||.|.|:|..|..|..|:..|:..:|:|..::||||:|.||
Human   111 --DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECP 173

  Fly   187 MNLQYFPMDRQLCHIEIESFGYTMRDIRYFWRDGLSSVGMSSEVELP-------QFRVLGHRQRA 244
            |.|..||||...|.::..|:.|...::.|.|     :.|....||:|       |:.::|....:
Human   174 MRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-----TKGPEKSVEVPKESSSLVQYDLIGQTVSS 233

  Fly   245 TEINLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLT 309
            ..|...||.|..:.......|.|||::||.|||..:.||:|.||||:|:.:.|||...|:|||||
Human   234 ETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLT 298

  Fly   310 MTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQ 374
            ||||..|...:|||:||..::|.::..||..||::|:|:|.|.|.. .|||.|    |.:|.::.
Human   299 MTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT-NIQMEK----AKRKTSKP 358

  Fly   375 KKQQLDGANQQQANP-----NPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHH 434
            .::......|::.:|     |.|||:................|....||             .|.
Human   359 PQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVG-------------NHS 410

  Fly   435 AHS-----HGHPHAPKQTVSNRPIGFS--NIQQNV-GTRGCSIVGPLFQEVRFKVHDPKA----- 486
            :.|     ......|:..:::.|..||  |..:.: ..|......|  ..:|......||
Human   411 SKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASP--TSIRTGYMPRKASVGSA 473

  Fly   487 ---HSKGGTLE---NTVNG-GRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAH 544
               |..|..|:   .|||. |..|..|..|.|               ...||.|.|
Human   474 STRHVFGSRLQRIKTTVNTIGATGKLSATPPP---------------SAPPPSGSG--------- 514

  Fly   545 LLHPGKVKKVKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYL 592
                                .|.||||:||:|||.|..||::||::||
Human   515 --------------------TSKIDKYARILFPVTFGAFNMVYWVVYL 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdl	NP_001261617.1	LGIC_ECD_GABAR_RDL-like	83..266	CDD:349809	64/190 (34%)
		Neur_chan_memb	274..588	CDD:397193	95/338 (28%)
GABRA4	NP_000800.2	Neur_chan_LBD	13..541	CDD:332142	180/565 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		7/50 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		8/63 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910